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Tolazamide

5 interactions on record

Tolazamide has 5 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Doxepin, Doxepin Hydrochloride. Patients taking Tolazamide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 5
Major: 2
Minor: 2

Major (2)

Tolazamide + Doxepin— ( 7.4 , 5.4 ) Tolazamide: A case of severe hypoglycemia has been reported. 7.5 Tolazamide A case of severe hypoglycemia …
Tolazamide + Doxepin Hydrochloride— ( 7.3 , 5.4 ) CNS Depressants and Sedating Antihistamines: Sedative effects may be increased with doxepin ( 7.4 , 5.4 ) …

Minor (2)

Tolazamide + Prazosin— Prazosin has been administered without adverse drug interaction with tolazamide in limited clinical experience.
Tolazamide + Prazosin Hydrochloride— Administered without adverse drug interaction in limited clinical experience.

Tolazamide + Doxepin⚠️Major

( 7.4 , 5.4 ) Tolazamide: A case of severe hypoglycemia has been reported. 7.5 Tolazamide A case of severe hypoglycemia has been reported in a type II diabetic patient maintained on tolazamide (1 g/day) 11 days after the addition of oral doxepin (75 mg/day).

Tolazamide + Doxepin Hydrochloride⚠️Major

( 7.3 , 5.4 ) CNS Depressants and Sedating Antihistamines: Sedative effects may be increased with doxepin ( 7.4 , 5.4 ) Tolazamide: A case of severe hypoglycemia has been reported. 7.5 Tolazamide A case of severe hypoglycemia has been reported in a type II diabetic patient maintained on tolazamide (1 g/day) 11 days after the addition of oral doxepin (75 mg/day).

Tolazamide + Prazosin🟢Minor

Prazosin has been administered without adverse drug interaction with tolazamide in limited clinical experience.

Tolazamide + Prazosin Hydrochloride🟢Minor

Administered without adverse drug interaction in limited clinical experience.

Tolazamide + Glipizide And Metformin Hydrochlorideℹ️Unknown

This fetotoxicity has been similarly noted with other sulfonylureas, such as tolbutamide and tolazamide.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.