Troleandomycin has 28 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 11 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Methylergonovine, Methylergonovine Maleate, Quinine Sulfate. Patients taking Troleandomycin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 28
- Contraindicated
- 3
- Major
- 11
- Moderate
- 9
Contraindicated (3)
- Troleandomycin + Methylergonovine— Macrolide antibiotic and strong CYP 3A4 inhibitor; should not be co-administered due to risk of vasospasm leading to cer…
- Troleandomycin + Methylergonovine Maleate— Macrolide antibiotic and strong CYP 3A4 inhibitor; rare reports of serious adverse events with ergot alkaloids including…
- Troleandomycin + Quinine Sulfate— CYP3A4 inhibitor causing increased quinine plasma levels. Concomitant administration should be avoided.
Major (11)
- Troleandomycin + Aprepitant— Intervention Avoid concomitant use of aprepitant Examples Moderate inhibitor: diltiazem Strong inhibitors: ketoconazole,…
- Troleandomycin + Depo-Medrol, Lidocaine, Isopropyl Alcohol— Troleandomycin inhibits cytochrome P450 3A4, resulting in increased plasma concentrations of corticosteroids.
- Troleandomycin + Eszopiclone— Strong CYP3A4 inhibitor expected to increase eszopiclone exposure and effects similarly to ketoconazole. Dose reduction …
- Troleandomycin + Fosaprepitant— Intervention Avoid concomitant use of fosaprepitant Examples Moderate inhibitor: diltiazemStrong inhibitors:ketoconazole…
- Troleandomycin + Fosaprepitant Dimeglumine— Intervention Avoid concomitant use of FOCINVEZ Examples Moderate inhibitor: diltiazem Strong inhibitors: ketoconazole, i…
- Troleandomycin + Hydrocortisone Sodium Succinate— Macrolide antibiotic causing significant decrease in corticosteroid clearance, potentially increasing corticosteroid lev…
- Troleandomycin + Levonorgestrel/Ethinyl Estradiol And Ethinyl Estradiol— CYP 3A4 inhibitor that increases plasma hormone levels and may increase risk of intrahepatic cholestasis during coadmini…
- Troleandomycin + Methylprednisolone Acetate— Macrolide antibiotic inhibits corticosteroid metabolism, increasing plasma concentrations.
- Troleandomycin + Quinine— CYP3A4 inhibitor that increases quinine plasma levels. Concomitant administration should be avoided.
- Troleandomycin + Tacrolimus— Strong CYP3A Inhibitors 3 : Protease inhibitors (e.g, nelfinavir, telaprevir, boceprevir, ritonavir), azole antifungals …
- Troleandomycin + Tacrolimus Extended-Release Capsules— Strong CYP3A Inhibitors : Protease inhibitors (e.g., nelfinavir, telaprevir, boceprevir, ritonavir), azole antifungals (…
Moderate (9)
- Troleandomycin + Carbamazepine— Macrolide CYP3A4 inhibitor that increases carbamazepine plasma levels; close monitoring and dosage adjustment may be req…
- Troleandomycin + Diazepam— CYP3A4 inhibitor that decreases diazepam elimination, potentially increasing adverse reactions.
- Troleandomycin + Hydrocortisone— Inhibits metabolism of corticosteroids and decreases their clearance, requiring dose titration to avoid steroid toxicity…
- Troleandomycin + Methylprednisolone— May inhibit the metabolism of methylprednisolone and decrease its clearance, requiring dose titration to avoid steroid t…
- Troleandomycin + Methylprednisolone Acetate, Lidocaine Hydrochloride, Povidine Iodine, Isopropyl Alcohol— Troleandomycin inhibits CYP3A4, potentially increasing plasma concentrations of corticosteroids.
- Troleandomycin + Methylprednisolone Sodium Succinate— Macrolide antibiotic that may cause a significant decrease in corticosteroid clearance, increasing corticosteroid levels…
- Troleandomycin + Prednisone— Inhibits metabolism of prednisone and decreases clearance, requiring dose titration to avoid steroid toxicity.
- Troleandomycin + Rapamycin— Weak/moderate CYP3A4/P-gp inhibitor that may increase sirolimus concentrations. Monitor and adjust dosage as needed.
- Troleandomycin + Rydapt— Strong CYP3A4 inhibitor that may increase midostaurin concentrations and risk of toxicity. Monitor for increased adverse…