Drospirenone has 23 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Aldosterone, Angiotensin Ii, Aprepitant. Patients taking Drospirenone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 23
- Moderate
- 20
Moderate (20)
- Drospirenone + Aldosterone— May increase serum potassium concentration when used with drospirenone.
- Drospirenone + Angiotensin Ii— May increase serum potassium concentration when used with drospirenone.
- Drospirenone + Aprepitant— May decrease systemic concentrations of hormonal contraceptives and diminish effectiveness or increase breakthrough blee…
- Drospirenone + Barbiturates— May decrease systemic concentrations of hormonal contraceptives and diminish effectiveness or increase breakthrough blee…
- Drospirenone + Bosentan— May decrease systemic concentrations of hormonal contraceptives and diminish effectiveness or increase breakthrough blee…
- Drospirenone + Carbamazepine— May decrease systemic concentrations of hormonal contraceptives and diminish effectiveness or increase breakthrough blee…
- Drospirenone + Efavirenz— May decrease systemic concentrations of hormonal contraceptives and diminish effectiveness or increase breakthrough blee…
- Drospirenone + Felbamate— May decrease systemic concentrations of hormonal contraceptives and diminish effectiveness or increase breakthrough blee…
- Drospirenone + Griseofulvin— May decrease systemic concentrations of hormonal contraceptives and diminish effectiveness or increase breakthrough blee…
- Drospirenone + Heparin— May increase serum potassium concentration when used with drospirenone.
- Drospirenone + Ketoconazole— Substances increasing the systemic concentrations of hormonal contraceptives (HCs): In a clinical drug-drug interaction …
- Drospirenone + Mao Inhibitors— May increase serum potassium concentration when used with drospirenone.
- Drospirenone + Nsaids— May increase serum potassium concentration when used with drospirenone.
- Drospirenone + Oxcarbazepine— May decrease systemic concentrations of hormonal contraceptives and diminish effectiveness or increase breakthrough blee…
- Drospirenone + Phenytoin— May decrease systemic concentrations of hormonal contraceptives and diminish effectiveness or increase breakthrough blee…
- Drospirenone + Potassium Supplements— May increase serum potassium concentration when used with drospirenone.
- Drospirenone + Rifabutin— May decrease systemic concentrations of hormonal contraceptives and diminish effectiveness or increase breakthrough blee…
- Drospirenone + Rifampin— May decrease systemic concentrations of hormonal contraceptives and diminish effectiveness or increase breakthrough blee…
- Drospirenone + Rufinamide— May decrease systemic concentrations of hormonal contraceptives and diminish effectiveness or increase breakthrough blee…
- Drospirenone + St. John'S Wort— May decrease systemic concentrations of hormonal contraceptives and diminish effectiveness or increase breakthrough blee…