Levomilnacipran Hydrochloride has 19 known drug interactions based on U.S. FDA drug labeling data. Of these, 7 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Isocarboxazid, Linezolid, Methylene Blue. Patients taking Levomilnacipran Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 19
- Contraindicated
- 7
- Moderate
- 12
Contraindicated (7)
- Levomilnacipran Hydrochloride + Isocarboxazid— MAOI that increases risk of serotonin syndrome when used with levomilnacipran. Contraindicated use.
- Levomilnacipran Hydrochloride + Linezolid— MAOI-like antibiotic that increases risk of serotonin syndrome when used with levomilnacipran. Contraindicated use.
- Levomilnacipran Hydrochloride + Methylene Blue— MAOI-like compound that increases risk of serotonin syndrome when used intravenously with levomilnacipran. Contraindicat…
- Levomilnacipran Hydrochloride + Monoamine Oxidase Inhibitors (Maois)— Concomitant use increases risk of serotonin syndrome. Contraindicated with MAOIs intended to treat psychiatric disorders…
- Levomilnacipran Hydrochloride + Phenelzine— MAOI that increases risk of serotonin syndrome when used with levomilnacipran. Contraindicated use.
- Levomilnacipran Hydrochloride + Selegiline— MAOI that increases risk of serotonin syndrome when used with levomilnacipran. Contraindicated use.
- Levomilnacipran Hydrochloride + Tranylcypromine— MAOI that increases risk of serotonin syndrome when used with levomilnacipran. Contraindicated use.
Moderate (12)
- Levomilnacipran Hydrochloride + Alcohol— Concomitant use may result in accelerated release of levomilnacipran. Avoid concomitant use.
- Levomilnacipran Hydrochloride + Amphetamine— Serotonergic drugs that increase risk of serotonin syndrome. Monitor for symptoms and discontinue if serotonin syndrome …
- Levomilnacipran Hydrochloride + Aspirin— Antiplatelet drug that may potentiate bleeding risk when used with levomilnacipran. Closely monitor for bleeding.
- Levomilnacipran Hydrochloride + Buspirone— Serotonergic drug that increases risk of serotonin syndrome. Monitor for symptoms and discontinue if serotonin syndrome …
- Levomilnacipran Hydrochloride + Clarithromycin— Strong CYP3A4 inhibitor that increases levomilnacipran exposure. Maximum recommended dose is 80 mg once daily.
- Levomilnacipran Hydrochloride + Itraconazole— Strong CYP3A4 inhibitor that increases levomilnacipran exposure. Maximum recommended dose is 80 mg once daily.
- Levomilnacipran Hydrochloride + Ketoconazole— Strong CYP3A4 inhibitor that increases levomilnacipran exposure. Maximum recommended dose is 80 mg once daily.
- Levomilnacipran Hydrochloride + Lithium— Serotonergic drug that increases risk of serotonin syndrome. Monitor for symptoms and discontinue if serotonin syndrome …
- Levomilnacipran Hydrochloride + St. John'S Wort— Serotonergic drug that increases risk of serotonin syndrome. Monitor for symptoms and discontinue if serotonin syndrome …
- Levomilnacipran Hydrochloride + Triptans— Serotonergic drugs that increase risk of serotonin syndrome. Monitor for symptoms and discontinue if serotonin syndrome …
- Levomilnacipran Hydrochloride + Tryptophan— Serotonergic drug that increases risk of serotonin syndrome. Monitor for symptoms and discontinue if serotonin syndrome …
- Levomilnacipran Hydrochloride + Warfarin— Anticoagulant that may potentiate bleeding risk when used with levomilnacipran. Closely monitor for bleeding.