Vortioxetine has 22 known drug interactions based on U.S. FDA drug labeling data. Of these, 6 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Isocarboxazid, Linezolid, Methylene Blue. Patients taking Vortioxetine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 22
- Contraindicated
- 6
- Moderate
- 15
Contraindicated (6)
- Vortioxetine + Isocarboxazid— Concomitant use with MAOIs increases risk of serotonin syndrome. Contraindicated with MAOI or within 14 days of stopping…
- Vortioxetine + Linezolid— Concomitant use increases risk of serotonin syndrome. Contraindicated with linezolid or within 21 days of stopping vorti…
- Vortioxetine + Methylene Blue— Concomitant intravenous use increases risk of serotonin syndrome. Contraindicated with IV methylene blue or within 21 da…
- Vortioxetine + Phenelzine— Concomitant use with MAOIs increases risk of serotonin syndrome. Contraindicated with MAOI or within 14 days of stopping…
- Vortioxetine + Selegiline— Concomitant use with MAOIs increases risk of serotonin syndrome. Contraindicated with MAOI or within 14 days of stopping…
- Vortioxetine + Tranylcypromine— Concomitant use with MAOIs increases risk of serotonin syndrome. Contraindicated with MAOI or within 14 days of stopping…
Moderate (15)
- Vortioxetine + Acetylsalicylic Acid— Antiplatelet agent may potentiate risk of bleeding when used with vortioxetine. Monitor patients for increased bleeding …
- Vortioxetine + Amphetamine— Serotonergic drugs that increase risk of serotonin syndrome when used with TRINTELLIX. Monitor for serotonin syndrome sy…
- Vortioxetine + Bupropion— Strong CYP2D6 inhibitor increases plasma concentrations of vortioxetine. Reduce TRINTELLIX dose by half when coadministe…
- Vortioxetine + Buspirone— Serotonergic drug that increases risk of serotonin syndrome when used with TRINTELLIX. Monitor for serotonin syndrome sy…
- Vortioxetine + Carbamazepine— Strong CYP inducer decreases plasma concentrations of vortioxetine. Consider increasing TRINTELLIX dose; maximum dose no…
- Vortioxetine + Fluoxetine— Strong CYP2D6 inhibitor increases plasma concentrations of vortioxetine. Reduce TRINTELLIX dose by half when coadministe…
- Vortioxetine + Lithium— Serotonergic drug that increases risk of serotonin syndrome when used with TRINTELLIX. Monitor for serotonin syndrome sy…
- Vortioxetine + Paroxetine— Strong CYP2D6 inhibitor increases plasma concentrations of vortioxetine. Reduce TRINTELLIX dose by half when coadministe…
- Vortioxetine + Phenytoin— Strong CYP inducer decreases plasma concentrations of vortioxetine. Consider increasing TRINTELLIX dose; maximum dose no…
- Vortioxetine + Quinidine— Strong CYP2D6 inhibitor increases plasma concentrations of vortioxetine. Reduce TRINTELLIX dose by half when coadministe…
- Vortioxetine + Rifampin— Strong CYP inducer decreases plasma concentrations of vortioxetine. Consider increasing TRINTELLIX dose; maximum dose no…
- Vortioxetine + St. John'S Wort— Serotonergic drug that increases risk of serotonin syndrome when used with TRINTELLIX. Monitor for serotonin syndrome sy…
- Vortioxetine + Triptans— Serotonergic drugs that increase risk of serotonin syndrome when used with TRINTELLIX. Monitor for serotonin syndrome sy…
- Vortioxetine + Tryptophan— Serotonergic drug that increases risk of serotonin syndrome when used with TRINTELLIX. Monitor for serotonin syndrome sy…
- Vortioxetine + Warfarin— Anticoagulant may potentiate risk of bleeding with vortioxetine. Carefully monitor international normalized ratio.