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Insulin Degludec And Liraglutide

Also known as: Xultophy 100/3.6

Insulin AnalogGLP-1 Receptor AgonistGlucagon-like Peptide-1 (GLP-1) Agonists

Route: Subcutaneous

Check Insulin Degludec And Liraglutide Interactions →

43 interactions on record⛔ Black Box Warning

Insulin Degludec And Liraglutide has 43 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Acidifying Agents, Albuterol, Alcohol. Patients taking Insulin Degludec And Liraglutide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 43
Moderate: 41

Moderate (41)

Insulin Degludec And Liraglutide + Acidifying Agents— May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Albuterol— Sympathomimetic agent that may decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring…
Insulin Degludec And Liraglutide + Alcohol— May increase or decrease blood glucose-lowering effect; dosage adjustment and increased glucose monitoring may be requir…
Insulin Degludec And Liraglutide + Amiloride Hydrochloride And Hydrochlorothiazide— Dosage adjustment of the antidiabetic drug may be required when used with hydrochlorothiazide.
Insulin Degludec And Liraglutide + Angiotensin Ii— May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Candesartan Cilexetil And Hydrochlorothiazide— Dosage adjustment of the antidiabetic drug may be required.
Insulin Degludec And Liraglutide + Chlorothiazide Sodium— Dosage adjustment of the antidiabetic drug may be required when used concurrently with chlorothiazide sodium.
Insulin Degludec And Liraglutide + Clonidine— May increase or decrease blood glucose-lowering effect and may blunt signs/symptoms of hypoglycemia; dosage adjustment a…
Insulin Degludec And Liraglutide + Clozapine— Atypical antipsychotic that may decrease blood glucose-lowering effect; dosage increases and increased glucose monitorin…
Insulin Degludec And Liraglutide + Corticosteroids— May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Danazol— May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Disopyramide— May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Diuretics— May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Epinephrine— Sympathomimetic agent that may decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring…
Insulin Degludec And Liraglutide + Estrogens— May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Fibrates— May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Fluoxetine— May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Glucagon— May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Guanethidine— May blunt signs and symptoms of hypoglycemia; increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Hydrochlorothiazide— Dosage adjustment of the antidiabetic drug may be required when used with hydrochlorothiazide.
Insulin Degludec And Liraglutide + Irbesartan And Hydrochlorothiazide— Dosage adjustment of antidiabetic drug may be required when coadministered with hydrochlorothiazide.
Insulin Degludec And Liraglutide + Isoniazid— May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Lithium— May increase or decrease blood glucose-lowering effect; dosage adjustment and increased glucose monitoring may be requir…
Insulin Degludec And Liraglutide + Macrolide Antibiotics— May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Mao Inhibitors— May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Monoamine Oxidase Inhibitors (Maois)— May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Niacin— May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Nonselective Beta-Adrenergic Antagonists— May increase or decrease blood glucose-lowering effect and may blunt signs/symptoms of hypoglycemia; dosage adjustment a…
Insulin Degludec And Liraglutide + Octreotide— Somatostatin analog that may increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be re…
Insulin Degludec And Liraglutide + Olanzapine— Atypical antipsychotic that may decrease blood glucose-lowering effect; dosage increases and increased glucose monitorin…
Insulin Degludec And Liraglutide + Oral Contraceptives— May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Pentamidine— May cause hypoglycemia followed sometimes by hyperglycemia; dosage adjustment and increased glucose monitoring may be re…
Insulin Degludec And Liraglutide + Pentoxifylline— May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Phenothiazines— May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Pramlintide— May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Protease Inhibitors— May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Reserpine— May blunt signs and symptoms of hypoglycemia; increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Salicylates— May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Somatropin— May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.
Insulin Degludec And Liraglutide + Terbutaline— Sympathomimetic agent that may decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring…
Insulin Degludec And Liraglutide + Thyroid Hormones— May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Acidifying Agents🟡Moderate

May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Albuterol🟡Moderate

Sympathomimetic agent that may decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Alcohol🟡Moderate

May increase or decrease blood glucose-lowering effect; dosage adjustment and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Amiloride Hydrochloride And Hydrochlorothiazide🟡Moderate

Dosage adjustment of the antidiabetic drug may be required when used with hydrochlorothiazide.

Insulin Degludec And Liraglutide + Angiotensin Ii🟡Moderate

May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Candesartan Cilexetil And Hydrochlorothiazide🟡Moderate

Dosage adjustment of the antidiabetic drug may be required.

Insulin Degludec And Liraglutide + Chlorothiazide Sodium🟡Moderate

Dosage adjustment of the antidiabetic drug may be required when used concurrently with chlorothiazide sodium.

Insulin Degludec And Liraglutide + Clonidine🟡Moderate

May increase or decrease blood glucose-lowering effect and may blunt signs/symptoms of hypoglycemia; dosage adjustment and increased glucose monitoring required.

Insulin Degludec And Liraglutide + Clozapine🟡Moderate

Atypical antipsychotic that may decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Corticosteroids🟡Moderate

May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Danazol🟡Moderate

May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Disopyramide🟡Moderate

May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Diuretics🟡Moderate

May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Epinephrine🟡Moderate

Sympathomimetic agent that may decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Estrogens🟡Moderate

May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Fibrates🟡Moderate

May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Fluoxetine🟡Moderate

May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Glucagon🟡Moderate

May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Guanethidine🟡Moderate

May blunt signs and symptoms of hypoglycemia; increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Hydrochlorothiazide🟡Moderate

Dosage adjustment of the antidiabetic drug may be required when used with hydrochlorothiazide.

Insulin Degludec And Liraglutide + Irbesartan And Hydrochlorothiazide🟡Moderate

Dosage adjustment of antidiabetic drug may be required when coadministered with hydrochlorothiazide.

Insulin Degludec And Liraglutide + Isoniazid🟡Moderate

May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Lithium🟡Moderate

May increase or decrease blood glucose-lowering effect; dosage adjustment and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Macrolide Antibiotics🟡Moderate

May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Mao Inhibitors🟡Moderate

May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Monoamine Oxidase Inhibitors (Maois)🟡Moderate

May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Niacin🟡Moderate

May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Nonselective Beta-Adrenergic Antagonists🟡Moderate

May increase or decrease blood glucose-lowering effect and may blunt signs/symptoms of hypoglycemia; dosage adjustment and increased glucose monitoring required.

Insulin Degludec And Liraglutide + Octreotide🟡Moderate

Somatostatin analog that may increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Olanzapine🟡Moderate

Atypical antipsychotic that may decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Oral Contraceptives🟡Moderate

May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Pentamidine🟡Moderate

May cause hypoglycemia followed sometimes by hyperglycemia; dosage adjustment and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Pentoxifylline🟡Moderate

May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Phenothiazines🟡Moderate

May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Pramlintide🟡Moderate

May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Protease Inhibitors🟡Moderate

May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Reserpine🟡Moderate

May blunt signs and symptoms of hypoglycemia; increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Salicylates🟡Moderate

May increase risk of hypoglycemia; dosage reductions and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Somatropin🟡Moderate

May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Terbutaline🟡Moderate

Sympathomimetic agent that may decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Thyroid Hormones🟡Moderate

May decrease blood glucose-lowering effect; dosage increases and increased glucose monitoring may be required.

Insulin Degludec And Liraglutide + Acetazolamideℹ️Unknown

Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics Intervention: Dosage reductions and increased frequency of glucose monitoring may be required when XULTOPHY 100/3.6 is coadministered with these drugs.

Insulin Degludec And Liraglutide + Somatostatinℹ️Unknown

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.