Dronedarone has 28 known drug interactions based on U.S. FDA drug labeling data. Of these, 11 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Clarithromycin, Class Iii Antiarrhythmics, Iobenguane I-123. Patients taking Dronedarone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 28
- Contraindicated
- 11
- Major
- 4
- Moderate
- 10
Contraindicated (11)
- Dronedarone + Clarithromycin— 7.2 Effects of Other Drugs on Dronedarone Ketoconazole and Other Potent CYP3A Inhibitors Concomitant use of ketoconazole…
- Dronedarone + Class Iii Antiarrhythmics— Contraindicated due to potential risk of torsade de pointes-type ventricular tachycardia.
- Dronedarone + Iobenguane I-123— Contraindicated due to potential risk of torsade de pointes-type ventricular tachycardia.
- Dronedarone + Itraconazole— 7.2 Effects of Other Drugs on Dronedarone Ketoconazole and Other Potent CYP3A Inhibitors Concomitant use of ketoconazole…
- Dronedarone + Ketoconazole— 7.2 Effects of Other Drugs on Dronedarone Ketoconazole and Other Potent CYP3A Inhibitors Concomitant use of ketoconazole…
- Dronedarone + Levoketoconazole— Concomitant use is contraindicated due to increased risk of QT prolongation and torsades de pointes.
- Dronedarone + Macrolide Antibiotics— Contraindicated due to potential risk of torsade de pointes-type ventricular tachycardia when prolonging QT interval.
- Dronedarone + Nirmatrelvir And Ritonavir— Co-administration contraindicated due to potential for cardiac arrhythmias.
- Dronedarone + Phenothiazines— Contraindicated due to potential risk of torsade de pointes-type ventricular tachycardia when prolonging QT interval.
- Dronedarone + Ritonavir— 7.2 Effects of Other Drugs on Dronedarone Ketoconazole and Other Potent CYP3A Inhibitors Concomitant use of ketoconazole…
- Dronedarone + Voriconazole— 7.2 Effects of Other Drugs on Dronedarone Ketoconazole and Other Potent CYP3A Inhibitors Concomitant use of ketoconazole…
Major (4)
- Dronedarone + Digoxin— Increases digoxin AUC by 150%. Requires monitoring and dose reduction of 30-50%.
- Dronedarone + Ezetimibe And Simvastatin— Do not exceed 10 mg/10 mg ezetimibe and simvastatin tablets daily due to increased myopathy risk.
- Dronedarone + Lovastatin— Increases risk of myopathy/rhabdomyolysis, particularly with higher doses of lovastatin.
- Dronedarone + Simvastatin— ( 7.2 ) Statins: Avoid simvastatin doses greater than 10 mg daily. 7.3 Effects of Dronedarone on Other Drugs Simvastatin…
Moderate (10)
- Dronedarone + Calcium Channel Blockers— May potentiate dronedarone's effects on conduction. Initiate with low dose and increase after ECG verification of tolera…
- Dronedarone + Cyp3a Inducers— Avoid concomitant use. May decrease dronedarone exposure and efficacy.
- Dronedarone + Dabigatran Etexilate— P-gp inhibitor requiring dosage reduction to 75 mg twice daily in patients with moderate renal impairment (CrCl 30-50 mL…
- Dronedarone + Dabigatran Etexilate Mesylate— P-gp inhibitor requiring dosage reduction to 75 mg twice daily in patients with moderate renal impairment (CrCl 30-50 mL…
- Dronedarone + Deferasirox— Deferasirox may induce CYP3A4 resulting in decreased dronedarone concentration. Monitor for reduced effectiveness.
- Dronedarone + Grapefruit Juice— Avoid concomitant use. May increase dronedarone exposure.
- Dronedarone + Nonselective Beta-Adrenergic Antagonists— May provoke excessive bradycardia. Initiate with low dose and increase after ECG verification of tolerability.
- Dronedarone + Rapamycin— Monitor and adjust dosage as needed. Dronedarone is a CYP3A and P-gp inhibitor that increases exposure of narrow therape…
- Dronedarone + Tacrolimus— Monitor and adjust dosage as needed. Dronedarone is a CYP3A and P-gp inhibitor that increases exposure of narrow therape…
- Dronedarone + Warfarin— Monitor INR after initiating dronedarone in patients taking warfarin.