Tamsulosin Hydrochloride has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Ketoconazole, Mao Inhibitors, Paroxetine. Patients taking Tamsulosin Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 10
- Contraindicated
- 1
- Major
- 2
- Moderate
- 3
Contraindicated (1)
- Tamsulosin Hydrochloride + Ketoconazole— Strong CYP3A4 inhibitor; increases tamsulosin Cmax by 2.2-fold and AUC by 2.8-fold. Contraindicated due to potential for…
Major (2)
- Tamsulosin Hydrochloride + Mao Inhibitors— Concomitant use can potentially cause symptomatic hypotension.
- Tamsulosin Hydrochloride + Paroxetine— Strong CYP2D6 inhibitor increases tamsulosin Cmax by 1.3-fold and AUC by 1.6-fold, with potential for significant exposu…
Moderate (3)
- Tamsulosin Hydrochloride + Cimetidine— Decreases tamsulosin clearance by 26%, resulting in moderate increase in AUC by 44%. Use with caution.
- Tamsulosin Hydrochloride + Erythromycin— Tamsulosin hydrochloride capsules should be used with caution in combination with moderate inhibitors of CYP3A4 (e.g., e…
- Tamsulosin Hydrochloride + Terbinafine— Moderate CYP2D6 inhibitor; use with caution. Effects on tamsulosin pharmacokinetics not fully evaluated.