Magnesium Sulfate Heptahydrate has 45 known drug interactions based on U.S. FDA drug labeling data. 29 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Adrenergic Blockers, Amlodipine, Atracurium. Patients taking Magnesium Sulfate Heptahydrate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 45
- Major
- 29
- Moderate
- 16
Major (29)
- Magnesium Sulfate Heptahydrate + Adrenergic Blockers— Excessive neuromuscular block has occurred; these drugs should be administered concomitantly with caution.
- Magnesium Sulfate Heptahydrate + Amlodipine— Exaggerated hypotensive response is possible with concomitant use. Monitor vital signs frequently; supportive care and/o…
- Magnesium Sulfate Heptahydrate + Atracurium— Potentiation and prolongation of neuromuscular blockade is possible with concomitant use. Monitor respiration and depth …
- Magnesium Sulfate Heptahydrate + Candesartan— Co-administration may result in hyperkalemia. Monitor serum potassium levels in such patients.
- Magnesium Sulfate Heptahydrate + Candesartan Cilexetil— Coadministration may result in hyperkalemia. Monitor serum potassium in such patients.
- Magnesium Sulfate Heptahydrate + Candesartan Cilexetil And Hydrochlorothiazide— Co-administration may result in hyperkalemia. Monitor serum potassium in such patients.
- Magnesium Sulfate Heptahydrate + Cardiac Glycosides— Serious changes in cardiac conduction and heart block may occur in digitalized patients; administer with extreme caution…
- Magnesium Sulfate Heptahydrate + Cisatracurium— Potentiation and prolongation of neuromuscular blockade is possible with concomitant use. Monitor respiration and depth …
- Magnesium Sulfate Heptahydrate + Cisatracurium Besylate— May prolong neuromuscular blockade action of cisatracurium besylate. Use peripheral nerve stimulator and monitor clinica…
- Magnesium Sulfate Heptahydrate + Clevidipine— Exaggerated hypotensive response is possible with concomitant use. Monitor vital signs frequently; supportive care and/o…
- Magnesium Sulfate Heptahydrate + Enalapril— May lead to significant increases in serum potassium.
- Magnesium Sulfate Heptahydrate + Enalapril Maleate— Potassium-containing salt substitutes may lead to significant increases in serum potassium when combined with enalapril.
- Magnesium Sulfate Heptahydrate + Felodipine— Exaggerated hypotensive response is possible with concomitant use. Monitor vital signs frequently; supportive care and/o…
- Magnesium Sulfate Heptahydrate + Fosinopril Sodium— Coadministration may result in hyperkalemia. Monitor serum potassium in such patients.
- Magnesium Sulfate Heptahydrate + Irbesartan— Concomitant use may lead to increases in serum potassium and hyperkalemia, sometimes severe. Monitor serum potassium.
- Magnesium Sulfate Heptahydrate + Isradipine— Exaggerated hypotensive response is possible with concomitant use. Monitor vital signs frequently; supportive care and/o…
- Magnesium Sulfate Heptahydrate + Lisinopril And Hydrochlorothiazide Tablets— Potassium-containing salt substitutes may lead to significant hyperkalemia when used with lisinopril which attenuates po…
- Magnesium Sulfate Heptahydrate + Nicardipine— Exaggerated hypotensive response is possible with concomitant use. Monitor vital signs frequently; supportive care and/o…
- Magnesium Sulfate Heptahydrate + Nifedipine— Exaggerated hypotensive response is possible with concomitant use. Monitor vital signs frequently; supportive care and/o…
- Magnesium Sulfate Heptahydrate + Nimodipine— Exaggerated hypotensive response is possible with concomitant use. Monitor vital signs frequently; supportive care and/o…
- Magnesium Sulfate Heptahydrate + Nisoldipine— Exaggerated hypotensive response is possible with concomitant use. Monitor vital signs frequently; supportive care and/o…
- Magnesium Sulfate Heptahydrate + Pancuronium— Potentiation and prolongation of neuromuscular blockade is possible with concomitant use. Monitor respiration and depth …
- Magnesium Sulfate Heptahydrate + Potassium Bicarbonate— Most salt substitutes contain substantial amounts of potassium; concomitant use could result in hyperkalemia.
- Magnesium Sulfate Heptahydrate + Propofol— Potentiation and prolongation of analgesia and CNS depression is possible. Monitor depth of CNS depression frequently an…
- Magnesium Sulfate Heptahydrate + Rocuronium— Potentiation and prolongation of neuromuscular blockade is possible with concomitant use. Monitor respiration and depth …
- Magnesium Sulfate Heptahydrate + Succinylcholine— Potentiation and prolongation of neuromuscular blockade is possible. Magnesium suppresses peripheral neuromuscular funct…
- Magnesium Sulfate Heptahydrate + Triamterene— Most contain substantial amounts of potassium; may promote serum potassium accumulation and hyperkalemia when used with …
- Magnesium Sulfate Heptahydrate + Triamterene And Hydrochlorothiazide— Salt substitutes containing substantial amounts of potassium may promote serum potassium accumulation and hyperkalemia w…
- Magnesium Sulfate Heptahydrate + Vecuronium— Potentiation and prolongation of neuromuscular blockade is possible with concomitant use. Monitor respiration and depth …
Moderate (16)
- Magnesium Sulfate Heptahydrate + Alcohol— Alcohol induces renal losses of magnesium.
- Magnesium Sulfate Heptahydrate + Amlodipine And Valsartan— Concomitant use with valsartan may increase serum potassium levels. Monitor potassium concentration.
- Magnesium Sulfate Heptahydrate + Amphotericin B— Amphotericin B induces renal losses of magnesium.
- Magnesium Sulfate Heptahydrate + Atracurium Besylate— May enhance the neuromuscular blocking action of atracurium.
- Magnesium Sulfate Heptahydrate + Barbiturates— Additive CNS depressant effects when used with magnesium; dosage should be adjusted with caution.
- Magnesium Sulfate Heptahydrate + Calcium Antagonists— CNS depression and peripheral transmission defects produced by magnesium may be antagonized by calcium.
- Magnesium Sulfate Heptahydrate + Cisplatin— Cisplatin induces renal losses of magnesium.
- Magnesium Sulfate Heptahydrate + Cyclosporine— Cyclosporine induces renal losses of magnesium.
- Magnesium Sulfate Heptahydrate + Digitalis Glycosides— Digitalis induces renal losses of magnesium.
- Magnesium Sulfate Heptahydrate + Diuretics— Diuretics induce renal losses of magnesium.
- Magnesium Sulfate Heptahydrate + Pyridostigmine Bromide— May enhance neuromuscular blockade and interfere with restoration of neuromuscular function when used with pyridostigmin…
- Magnesium Sulfate Heptahydrate + Sacubitril And Valsartan— May lead to increased serum potassium. Monitor potassium levels.
- Magnesium Sulfate Heptahydrate + Succinylcholine Chloride— May enhance the neuromuscular blocking action of succinylcholine.
- Magnesium Sulfate Heptahydrate + Topical Local Anesthetics— Additive CNS depressant effects when used with magnesium; dosage should be adjusted with caution.
- Magnesium Sulfate Heptahydrate + Trandolapril— Can increase risk of hyperkalemia when used concomitantly with trandolapril. Use with caution and monitor serum potassiu…
- Magnesium Sulfate Heptahydrate + Trandolapril Tablets— Concomitant use with ACE inhibitors increases risk of hyperkalemia. Use with caution and appropriate monitoring of serum…