Clonazepam has 38 known drug interactions based on U.S. FDA drug labeling data. 12 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acidifying Agents, Alcohol, Barbiturates. Patients taking Clonazepam should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 38
- Major
- 12
- Moderate
- 5
- Minor
- 5
Major (12)
- Clonazepam + Acidifying Agents— Antianxiety agents potentiate CNS-depressant action of clonazepam.
- Clonazepam + Alcohol— CNS-depressant action of clonazepam may be potentiated by alcohol, increasing risk of sedation and respiratory depressio…
- Clonazepam + Barbiturates— CNS-depressant action of clonazepam may be potentiated by barbiturates, increasing risk of sedation and respiratory depr…
- Clonazepam + Butyrophenones— Potentiates CNS-depressant action of clonazepam.
- Clonazepam + Carbamazepine— Carbamazepine induces clonazepam metabolism, causing approximately 38% decrease in plasma clonazepam levels.
- Clonazepam + Haloperidol— Butyrophenone antipsychotics potentiate the CNS-depressant action of clonazepam.
- Clonazepam + Lamotrigine— Lamotrigine induces clonazepam metabolism, causing approximately 38% decrease in plasma clonazepam levels.
- Clonazepam + Monoamine Oxidase Inhibitors (Maois)— MAOIs potentiate CNS-depressant action of clonazepam.
- Clonazepam + Oral Anticoagulants— Potentiate CNS-depressant action of clonazepam.
- Clonazepam + Phenobarbital— Phenobarbital induces clonazepam metabolism, causing approximately 38% decrease in plasma clonazepam levels.
- Clonazepam + Phenothiazines— Potentiate CNS-depressant action of clonazepam.
- Clonazepam + Phenytoin— Phenytoin induces clonazepam metabolism, causing approximately 30% decrease in plasma clonazepam levels.
Moderate (5)
- Clonazepam + Azole Antifungals— Cytochrome P-450 3A inhibitors that may increase clonazepam levels; should be used cautiously in patients receiving clon…
- Clonazepam + Diazepam— Although early studies reported an increased risk of congenital malformations with diazepam and chlordiazepoxide, there …
- Clonazepam + Fluconazole— Should be used cautiously as it may impair clonazepam metabolism leading to exaggerated concentrations and effects.
- Clonazepam + Propantheline— Anticholinergic agent decreases clonazepam AUC by 10% and Cmax by 20% when given with clonazepam orally disintegrating t…
- Clonazepam + Vigabatrin— Vigabatrin may moderately increase the Cmax of clonazepam, resulting in an increase of clonazepam-associated adverse rea…
Minor (5)
- Clonazepam + Felbamate— CYP2C19 inhibitor and CYP3A4 inducer that does not affect clonazepam pharmacokinetics.
- Clonazepam + Fluoxetine— Fluoxetine does not affect the pharmacokinetics of clonazepam.
- Clonazepam + Lacosamide— Steady-state plasma concentrations of clonazepam were not affected by concomitant lacosamide at any dose in clinical stu…
- Clonazepam + Ranitidine— Agent that decreases stomach acidity; literature suggests it does not greatly alter clonazepam pharmacokinetics.
- Clonazepam + Sertraline— Weak CYP3A4 inducer that does not affect clonazepam pharmacokinetics.