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Enalapril Maleate Oral Solution

Also known as: Enalapril Maleate Oral Solution

Route: Oral

Check Enalapril Maleate Oral Solution Interactions →

9 interactions on record⛔ Black Box Warning

Enalapril Maleate Oral Solution has 9 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Aliskiren, Lithium, Amiloride. Patients taking Enalapril Maleate Oral Solution should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 9
Major: 2
Moderate: 6
Minor: 1

Major (2)

Enalapril Maleate Oral Solution + Aliskiren— Dual RAS blockade increases risk of hypotension, hyperkalemia, and acute renal failure. Contraindicated in diabetic pati…
Enalapril Maleate Oral Solution + Lithium— Concomitant use may cause lithium toxicity, generally reversible. Monitor serum lithium levels frequently.

Moderate (6)

Enalapril Maleate Oral Solution + Amiloride— Potassium-sparing diuretic may lead to significant increases in serum potassium when combined with enalapril. Avoid in h…
Enalapril Maleate Oral Solution + Enalapril— (7.4) 7.1 Non-Steroidal Anti-Inflammatory Agents (NSAIDs) Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibit…
Enalapril Maleate Oral Solution + Indomethacin— May result in deterioration of renal function including acute renal failure in elderly, volume-depleted, or renally comp…
Enalapril Maleate Oral Solution + Spironolactone— Potassium-sparing diuretic may lead to significant increases in serum potassium when combined with enalapril. Avoid in h…
Enalapril Maleate Oral Solution + Sulindac— May result in deterioration of renal function including acute renal failure in elderly, volume-depleted, or renally comp…
Enalapril Maleate Oral Solution + Triamterene— Potassium-sparing diuretic may lead to significant increases in serum potassium when combined with enalapril. Avoid in h…

Minor (1)

Enalapril Maleate Oral Solution + Sodium Aurothiomalate— Rarely causes nitritoid reactions (facial flushing, nausea, vomiting, hypotension) with injectable gold and ACE inhibito…

Enalapril Maleate Oral Solution + Aliskiren⚠️Major

Dual RAS blockade increases risk of hypotension, hyperkalemia, and acute renal failure. Contraindicated in diabetic patients; avoid in renal impairment.

Enalapril Maleate Oral Solution + Lithium⚠️Major

Concomitant use may cause lithium toxicity, generally reversible. Monitor serum lithium levels frequently.

Enalapril Maleate Oral Solution + Amiloride🟡Moderate

Potassium-sparing diuretic may lead to significant increases in serum potassium when combined with enalapril. Avoid in heart failure patients.

Enalapril Maleate Oral Solution + Enalapril🟡Moderate

(7.4) 7.1 Non-Steroidal Anti-Inflammatory Agents (NSAIDs) Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, co-administration of NSAIDs, including selective COX-2 inhibitors, with ACE inhibitors, including enalapril, may result in deterioration of renal function, including possible acute renal failure. Monitor renal function periodically in patients receiving enalapril and NSAID therapy. In a clinical pharmacology study, indomethacin or sulindac was administered to hypertensive patients receiving enalapril maleate.

Enalapril Maleate Oral Solution + Indomethacin🟡Moderate

May result in deterioration of renal function including acute renal failure in elderly, volume-depleted, or renally compromised patients. NSAIDs may diminish antihypertensive effect.

Enalapril Maleate Oral Solution + Spironolactone🟡Moderate

Potassium-sparing diuretic may lead to significant increases in serum potassium when combined with enalapril. Avoid in heart failure patients.

Enalapril Maleate Oral Solution + Sulindac🟡Moderate

May result in deterioration of renal function including acute renal failure in elderly, volume-depleted, or renally compromised patients. NSAIDs may diminish antihypertensive effect.

Enalapril Maleate Oral Solution + Triamterene🟡Moderate

Potassium-sparing diuretic may lead to significant increases in serum potassium when combined with enalapril. Avoid in heart failure patients.

Enalapril Maleate Oral Solution + Sodium Aurothiomalate🟢Minor

Rarely causes nitritoid reactions (facial flushing, nausea, vomiting, hypotension) with injectable gold and ACE inhibitor therapy.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.