Bupropion Hcl Er has 24 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Clopidogrel, Ticlopidine, Amantadine. Patients taking Bupropion Hcl Er should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 24
- Contraindicated
- 2
- Major
- 3
- Moderate
- 19
Contraindicated (2)
- Bupropion Hcl Er + Clopidogrel— Coadministration not recommended due to increased bupropion exposure and decreased hydroxybupropion exposure.
- Bupropion Hcl Er + Ticlopidine— Coadministration not recommended due to increased bupropion exposure and decreased hydroxybupropion exposure.
Major (3)
- Bupropion Hcl Er + Amantadine— CNS toxicity can occur when used concomitantly with bupropion.
- Bupropion Hcl Er + Levodopa— CNS toxicity can occur when used concomitantly with bupropion.
- Bupropion Hcl Er + Monoamine Oxidase Inhibitors (Maois)— Increased risk of hypertensive reactions when used concomitantly with bupropion.
Moderate (19)
- Bupropion Hcl Er + Carbamazepine— May induce metabolism of bupropion and decrease bupropion exposure; dose increase may be necessary.
- Bupropion Hcl Er + Desipramine— Bupropion inhibits CYP2D6 and can increase desipramine concentrations; consider dose reduction of desipramine.
- Bupropion Hcl Er + Efavirenz— Dose increase may be necessary as concomitant treatment decreases bupropion and hydroxybupropion exposure.
- Bupropion Hcl Er + Flecainide— Bupropion inhibits CYP2D6 and can increase flecainide concentrations; consider dose reduction of flecainide.
- Bupropion Hcl Er + Fluoxetine— Bupropion inhibits CYP2D6 and can increase fluoxetine concentrations; consider dose reduction of fluoxetine.
- Bupropion Hcl Er + Haloperidol— Bupropion inhibits CYP2D6 and can increase haloperidol concentrations; consider dose reduction of haloperidol.
- Bupropion Hcl Er + Imipramine— Bupropion inhibits CYP2D6 and can increase imipramine concentrations; consider dose reduction of imipramine.
- Bupropion Hcl Er + Lopinavir— Dose increase may be necessary as concomitant treatment decreases bupropion and hydroxybupropion exposure.
- Bupropion Hcl Er + Metoprolol— Bupropion inhibits CYP2D6 and can increase metoprolol concentrations; consider dose reduction of metoprolol.
- Bupropion Hcl Er + Nortriptyline— Bupropion inhibits CYP2D6 and can increase nortriptyline concentrations; consider dose reduction of nortriptyline.
- Bupropion Hcl Er + Paroxetine— Bupropion inhibits CYP2D6 and can increase paroxetine concentrations; consider dose reduction of paroxetine.
- Bupropion Hcl Er + Phenobarbital— May induce metabolism of bupropion and decrease bupropion exposure; dose increase may be necessary.
- Bupropion Hcl Er + Phenytoin— May induce metabolism of bupropion and decrease bupropion exposure; dose increase may be necessary.
- Bupropion Hcl Er + Propafenone— Bupropion inhibits CYP2D6 and can increase propafenone concentrations; consider dose reduction of propafenone.
- Bupropion Hcl Er + Risperidone— Bupropion inhibits CYP2D6 and can increase risperidone concentrations; consider dose reduction of risperidone.
- Bupropion Hcl Er + Ritonavir— Dose increase may be necessary as concomitant treatment decreases bupropion and hydroxybupropion exposure.
- Bupropion Hcl Er + Sertraline— Bupropion inhibits CYP2D6 and can increase sertraline concentrations; consider dose reduction of sertraline.
- Bupropion Hcl Er + Thioridazine— Bupropion inhibits CYP2D6 and can increase thioridazine concentrations; consider dose reduction of thioridazine.
- Bupropion Hcl Er + Venlafaxine— Bupropion inhibits CYP2D6 and can increase venlafaxine concentrations; consider dose reduction of venlafaxine.