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Codeine Phosphate And Chlorpheniramine Maleate

Also known as: Tuxarin

Route: Oral

Check Codeine Phosphate And Chlorpheniramine Maleate Interactions →

8 interactions on record⛔ Black Box Warning

Codeine Phosphate And Chlorpheniramine Maleate has 8 known drug interactions based on U.S. FDA drug labeling data. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carbamazepine, Erythromycin, Ketoconazole. Patients taking Codeine Phosphate And Chlorpheniramine Maleate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 8
Major: 7
Moderate: 1

Major (7)

Codeine Phosphate And Chlorpheniramine Maleate + Carbamazepine— CYP3A4 inducer can result in lower codeine and morphine levels, decreasing efficacy or causing withdrawal syndrome. Avoi…
Codeine Phosphate And Chlorpheniramine Maleate + Erythromycin— CYP3A4 inhibitor may increase codeine plasma concentrations leading to greater morphine levels and potentially fatal res…
Codeine Phosphate And Chlorpheniramine Maleate + Ketoconazole— ketoconazole), or protease inhibitors (e.g., ritonavir), may result in an increase in codeine plasma concentrations with…
Codeine Phosphate And Chlorpheniramine Maleate + Muscle Relaxants— Avoid concomitant use with codeine.
Codeine Phosphate And Chlorpheniramine Maleate + Phenytoin— Avoid concomitant use; may increase phenytoin levels and cause phenytoin toxicity. Chlorpheniramine may inhibit hepatic …
Codeine Phosphate And Chlorpheniramine Maleate + Rifampin— CYP3A4 inducer can result in lower codeine and morphine levels, decreasing efficacy or causing withdrawal syndrome. Avoi…
Codeine Phosphate And Chlorpheniramine Maleate + Ritonavir— ketoconazole), or protease inhibitors (e.g., ritonavir), may result in an increase in codeine plasma concentrations with…

Moderate (1)

Codeine Phosphate And Chlorpheniramine Maleate + Diuretics— Codeine may reduce the efficacy of diuretics. Monitor for reduced effect.

Codeine Phosphate And Chlorpheniramine Maleate + Carbamazepine⚠️Major

CYP3A4 inducer can result in lower codeine and morphine levels, decreasing efficacy or causing withdrawal syndrome. Avoid concomitant use.

Codeine Phosphate And Chlorpheniramine Maleate + Erythromycin⚠️Major

CYP3A4 inhibitor may increase codeine plasma concentrations leading to greater morphine levels and potentially fatal respiratory depression. Avoid concomitant use.

Codeine Phosphate And Chlorpheniramine Maleate + Ketoconazole⚠️Major

ketoconazole), or protease inhibitors (e.g., ritonavir), may result in an increase in codeine plasma concentrations with subsequently greater metabolism by cytochrome CYP2D6, resulting in greater morphine levels, which could increase or prolong adverse reactions and may cause potentially fatal respiratory depression, particularly when an inhibitor is added after a stable dose of TUXARIN ER is achieved [ see Warnings and Precautions (5.8) ].

Codeine Phosphate And Chlorpheniramine Maleate + Muscle Relaxants⚠️Major

Avoid concomitant use with codeine.

Codeine Phosphate And Chlorpheniramine Maleate + Phenytoin⚠️Major

Avoid concomitant use; may increase phenytoin levels and cause phenytoin toxicity. Chlorpheniramine may inhibit hepatic metabolism of phenytoin.

Codeine Phosphate And Chlorpheniramine Maleate + Rifampin⚠️Major

CYP3A4 inducer can result in lower codeine and morphine levels, decreasing efficacy or causing withdrawal syndrome. Avoid concomitant use.

Codeine Phosphate And Chlorpheniramine Maleate + Ritonavir⚠️Major

Codeine Phosphate And Chlorpheniramine Maleate + Diuretics🟡Moderate

Codeine may reduce the efficacy of diuretics. Monitor for reduced effect.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.