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Telmisartan, Amlodipine And Indapamide

Also known as: Widaplik

Thiazide-like DiureticAngiotensin 2 Receptor BlockerAngiotensin 2 Receptor Antagonists

Route: Oral

Check Telmisartan, Amlodipine And Indapamide Interactions →

10 interactions on record⛔ Black Box Warning

Telmisartan, Amlodipine And Indapamide has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Aliskiren, Digoxin, Lithium. Patients taking Telmisartan, Amlodipine And Indapamide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 10
Contraindicated: 1
Major: 3
Moderate: 6

Contraindicated (1)

Telmisartan, Amlodipine And Indapamide + Aliskiren— Do not co-administer aliskiren with Widaplik in patients with diabetes. Avoid use in patients with renal impairment (GFR…

Major (3)

Telmisartan, Amlodipine And Indapamide + Digoxin— Telmisartan co-administration increases digoxin peak plasma concentration (49%) and trough concentration (20%), requirin…
Telmisartan, Amlodipine And Indapamide + Lithium— Increases in serum lithium concentrations and toxicity reported with telmisartan. Monitor serum lithium levels during co…
Telmisartan, Amlodipine And Indapamide + Nsaids— Increased risk of renal impairment and loss of antihypertensive effect, especially in elderly, volume-depleted, or renal…

Moderate (6)

Telmisartan, Amlodipine And Indapamide + Aldosterone— 7 DRUG INTERACTIONS NSAIDs: Increased risk of renal impairment and loss of anti-hypertensive effect ( 7.1 ) If simvastat…
Telmisartan, Amlodipine And Indapamide + Amlodipine— 7.2 Drug Interactions with Amlodipine Impact of other drugs on amlodipine CYP3A Inhibitors Co-administration with CYP3A …
Telmisartan, Amlodipine And Indapamide + Indapamide— Monitor serum lithium levels during concomitant use [see Drug Interactions with Indapamide ( 7.3 )] . 7.3 Drug Interacti…
Telmisartan, Amlodipine And Indapamide + Sildenafil— Monitor for hypotension when sildenafil is co-administered with Widaplik.
Telmisartan, Amlodipine And Indapamide + Simvastatin— 7 DRUG INTERACTIONS NSAIDs: Increased risk of renal impairment and loss of anti-hypertensive effect ( 7.1 ) If simvastat…
Telmisartan, Amlodipine And Indapamide + Telmisartan— 7 DRUG INTERACTIONS NSAIDs: Increased risk of renal impairment and loss of anti-hypertensive effect ( 7.1 ) If simvastat…

Telmisartan, Amlodipine And Indapamide + Aliskiren⛔Contraindicated

Do not co-administer aliskiren with Widaplik in patients with diabetes. Avoid use in patients with renal impairment (GFR <60 mL/min).

Telmisartan, Amlodipine And Indapamide + Digoxin⚠️Major

Telmisartan co-administration increases digoxin peak plasma concentration (49%) and trough concentration (20%), requiring therapeutic monitoring.

Telmisartan, Amlodipine And Indapamide + Lithium⚠️Major

Increases in serum lithium concentrations and toxicity reported with telmisartan. Monitor serum lithium levels during concomitant use.

Telmisartan, Amlodipine And Indapamide + Nsaids⚠️Major

Increased risk of renal impairment and loss of antihypertensive effect, especially in elderly, volume-depleted, or renally compromised patients. May result in acute renal failure.

Telmisartan, Amlodipine And Indapamide + Aldosterone🟡Moderate

Telmisartan, Amlodipine And Indapamide + Amlodipine🟡Moderate

7.2 Drug Interactions with Amlodipine Impact of other drugs on amlodipine CYP3A Inhibitors Co-administration with CYP3A inhibitors (moderate and strong) results in increased systemic exposure to amlodipine and may require dose reduction. CYP3A Inducers No information is available on the quantitative effects of CYP3A inducers on amlodipine. Impact of amlodipine on other drugs Simvastatin: Co-administration of simvastatin with amlodipine increases the systemic exposure of simvastatin.

Telmisartan, Amlodipine And Indapamide + Indapamide🟡Moderate

Monitor serum lithium levels during concomitant use [see Drug Interactions with Indapamide ( 7.3 )] . 7.3 Drug Interactions with Indapamide Lithium: In general, diuretics should not be given concomitantly with lithium because they reduce its renal clearance and add a high risk of lithium toxicity. Norepinephrine: Indapamide, like thiazide diuretics, may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use.

Telmisartan, Amlodipine And Indapamide + Sildenafil🟡Moderate

Monitor for hypotension when sildenafil is co-administered with Widaplik.

Telmisartan, Amlodipine And Indapamide + Simvastatin🟡Moderate

7 DRUG INTERACTIONS NSAIDs: Increased risk of renal impairment and loss of anti-hypertensive effect ( 7.1 ) If simvastatin is co-administered with Widaplik, do not exceed doses greater than 20 mg daily of simvastatin ( 7.2 ) Do not co-administer aliskiren with Widaplik in patients with diabetes ( 7.1 ) 7.1 Drug Interactions with Telmisartan Aliskiren and other renin-angiotensin-aldosterone system (RAAS) inhibitors: Do not co-administer aliskiren with Widaplik in patients with diabetes. Impact of amlodipine on other drugs Simvastatin: Co-administration of simvastatin with amlodipine increases the systemic exposure of simvastatin. Limit the dose of simvastatin in patients on Widaplik to 20 mg daily.

Telmisartan, Amlodipine And Indapamide + Telmisartan🟡Moderate

7 DRUG INTERACTIONS NSAIDs: Increased risk of renal impairment and loss of anti-hypertensive effect ( 7.1 ) If simvastatin is co-administered with Widaplik, do not exceed doses greater than 20 mg daily of simvastatin ( 7.2 ) Do not co-administer aliskiren with Widaplik in patients with diabetes ( 7.1 ) 7.1 Drug Interactions with Telmisartan Aliskiren and other renin-angiotensin-aldosterone system (RAAS) inhibitors: Do not co-administer aliskiren with Widaplik in patients with diabetes. Digoxin: When telmisartan was co-administered with digoxin, median increases in digoxin peak plasma concentration (49%) and in trough concentration (20%) were observed. Lithium: Increases in serum lithium concentrations and toxicity have been reported during concomitant administration of lithium with angiotensin II receptor antagonists including telmisartan.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.