Valganciclovir has 40 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 15 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Imipenem And Cilastatin, Adriamycin, Amphotericin B. Patients taking Valganciclovir should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 40
- Contraindicated
- 1
- Major
- 15
- Moderate
- 16
Contraindicated (1)
- Valganciclovir + Imipenem And Cilastatin— Generalized seizures have been reported in patients receiving ganciclovir and imipenem-cilastatin. Coadministration is n…
Major (15)
- Valganciclovir + Adriamycin— Associated with myelosuppression or nephrotoxicity. Coadministration should be considered only if potential benefits out…
- Valganciclovir + Amphotericin B— Risk of nephrotoxicity may be increased when coadministered with valganciclovir. Monitor renal function closely.
- Valganciclovir + Cyclosporine— Risk of nephrotoxicity may be increased when coadministered with valganciclovir. Monitor renal function closely.
- Valganciclovir + Dapsone— Associated with myelosuppression or nephrotoxicity. Coadministration should be considered only if potential benefits out…
- Valganciclovir + Doxorubicin— Associated with myelosuppression or nephrotoxicity. Coadministration should be considered only if potential benefits out…
- Valganciclovir + Flucytosine— Associated with myelosuppression or nephrotoxicity. Coadministration should be considered only if potential benefits out…
- Valganciclovir + Hydroxyurea— Associated with myelosuppression or nephrotoxicity. Coadministration should be considered only if potential benefits out…
- Valganciclovir + Maribavir— LIVTENCITY may antagonize the antiviral activity of valganciclovir by inhibiting human CMV pUL97 kinase, which is requir…
- Valganciclovir + Mycophenolate Mofetil— Risk of hematological and renal toxicity may be increased. Monitor for ganciclovir and MMF toxicity.
- Valganciclovir + Pentamidine— Associated with myelosuppression or nephrotoxicity. Coadministration should be considered only if potential benefits out…
- Valganciclovir + Sulfamethoxazole And Trimethoprim— Associated with myelosuppression or nephrotoxicity. Coadministration should be considered only if potential benefits out…
- Valganciclovir + Tacrolimus— Associated with myelosuppression or nephrotoxicity. Coadministration should be considered only if potential benefits out…
- Valganciclovir + Vinblastine— Associated with myelosuppression or nephrotoxicity. Coadministration should be considered only if potential benefits out…
- Valganciclovir + Vincristine— Associated with myelosuppression or nephrotoxicity. Coadministration should be considered only if potential benefits out…
- Valganciclovir + Zidovudine— Associated with myelosuppression or nephrotoxicity. Coadministration should be considered only if potential benefits out…
Moderate (16)
- Valganciclovir + Alafenamide— Eliminated by active tubular secretion; coadministration may increase tenofovir and valganciclovir concentrations, incre…
- Valganciclovir + Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate— Coadministration may increase concentrations of valganciclovir and renally eliminated drugs, increasing risk of adverse …
- Valganciclovir + Cilastatin— Table 9 Established and Other Potentially Significant Drug Interactions with Ganciclovir Name of the Concomitant Drug Ch…
- Valganciclovir + Didanosine— Valganciclovir may increase didanosine concentrations. Patients should be closely monitored for didanosine toxicity.
- Valganciclovir + Efavirenz, Emtricitabine And Tenofovir Disoproxil Fumarate— Eliminated by active tubular secretion; may increase concentrations of valganciclovir and/or emtricitabine/tenofovir.
- Valganciclovir + Efavirenz, Lamivudine And Tenofovir Disoproxil Fumarate— Coadministration may increase concentrations of tenofovir and/or valganciclovir due to competition for active tubular se…
- Valganciclovir + Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate— Valganciclovir is eliminated by active tubular secretion; coadministration may increase concentrations of valganciclovir…
- Valganciclovir + Emtricitabine And Tenofovir Alafenamide— Coadministration may increase concentrations of FTC, tenofovir, and valganciclovir due to competition for active tubular…
- Valganciclovir + Emtricitabine And Tenofovir Disoproxil Fumarate— Coadministration may increase concentrations of valganciclovir and/or tenofovir due to competition for renal tubular sec…
- Valganciclovir + Emtricitabine, Rilpivirine And Tenofovir Disoproxil Fumarate— Coadministration may increase serum concentrations of emtricitabine, tenofovir, and/or valganciclovir due to competition…
- Valganciclovir + Emtricitabine, Rilpivirine, Tenofovir Disoproxil Fumarate— Coadministration may increase serum concentrations of FTC, tenofovir, and/or valganciclovir due to competition for activ…
- Valganciclovir + Emtricitabine/Tdf— Coadministration may increase concentrations of FTC, tenofovir, and/or valganciclovir due to competition for active tubu…
- Valganciclovir + Lamivudine And Tenofovir Disoproxil Fumarate— May increase serum tenofovir concentrations and/or increase concentrations of other renally eliminated drugs.
- Valganciclovir + Mycophenilic Acid— ( 5.2 , 7.8 ) Acyclovir, Valacyclovir, Ganciclovir, Valganciclovir, and Other Drugs that Undergo Renal Tubular Secretion…
- Valganciclovir + Probenecid— Probenecid increases ganciclovir concentrations. Monitor patients for evidence of ganciclovir toxicity.
- Valganciclovir + Tenofovir Disoproxil Fumarate— Coadministration may increase tenofovir concentrations due to active tubular secretion competition. Monitor for evidence…