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Dichlorphenamide

Also known as: Keveyis, Ormalvi

Carbonic Anhydrase InhibitorCarbonic Anhydrase Inhibitors

Route: Oral

34 interactions on record

Dichlorphenamide has 34 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 20 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Aspirin, Aspirin (High-Dose), Alogliptin And Metformin Hydrochloride. Patients taking Dichlorphenamide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 34
Contraindicated: 2
Major: 20
Moderate: 10

Contraindicated (2)

Dichlorphenamide + Aspirin— High-dose aspirin with dichlorphenamide is contraindicated due to risk of anorexia, tachypnea, lethargy, and coma. Low-d…
Dichlorphenamide + Aspirin (High-Dose)— High-dose aspirin with dichlorphenamide causes anorexia, tachypnea, lethargy, and coma. Concomitant use is contraindicat…

Major (20)

Dichlorphenamide + Alogliptin And Metformin Hydrochloride— Carbonic anhydrase inhibitor that may increase risk of lactic acidosis by decreasing serum bicarbonate and inducing meta…
Dichlorphenamide + Dapagliflozin And Metformin Hydrochloride— Carbonic anhydrase inhibitor that may increase risk for lactic acidosis when used concomitantly.
Dichlorphenamide + Empagliflozin And Metformin Hydrochloride— Dichlorphenamide causes decreased serum bicarbonate and metabolic acidosis; concomitant use may increase risk of lactic …
Dichlorphenamide + Empagliflozin, Linagliptin, Metformin Hydrochloride— Dichlorphenamide causes decreased serum bicarbonate and metabolic acidosis; concomitant use with TRIJARDY XR may increas…
Dichlorphenamide + Empagliflozin, Metformin Hydrochloride— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk of lactic acidosis when used with SY…
Dichlorphenamide + Ertugliflozin And Metformin Hydrochloride— Increases risk of lactic acidosis due to decreased serum bicarbonate and metabolic acidosis when used with metformin.
Dichlorphenamide + Famotidine— Concomitant use is not recommended as dichlorphenamide inhibits OAT1 transporters, increasing famotidine plasma exposure…
Dichlorphenamide + Glyburide And Metformin Hydrochloride— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis when used with g…
Dichlorphenamide + Linagliptin And Metformin Hydrochloride— Carbonic anhydrase inhibitor that decreases serum bicarbonate and induces metabolic acidosis, increasing risk of lactic …
Dichlorphenamide + Metformin— Carbonic anhydrase inhibitor that decreases serum bicarbonate and induces metabolic acidosis, increasing risk for lactic…
Dichlorphenamide + Metformin Er 500 Mg— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk of lactic acidosis with metformin.
Dichlorphenamide + Metformin Hydrochloride— Carbonic anhydrase inhibitor that may increase risk of lactic acidosis by decreasing serum bicarbonate and inducing meta…
Dichlorphenamide + Metformin Hydrochloride Extended-Release Tablets— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis when used with m…
Dichlorphenamide + Metformin Hydrochloride Tablet— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis when used with m…
Dichlorphenamide + Methotrexate— Concomitant use is not recommended as dichlorphenamide inhibits OAT1 transporters, increasing methotrexate plasma exposu…
Dichlorphenamide + Oseltamivir— Concomitant use is not recommended as dichlorphenamide inhibits OAT1 transporters, increasing oseltamivir plasma exposur…
Dichlorphenamide + Pioglitazole And Metformin Hydrochloride— Carbonic anhydrase inhibitor decreases serum bicarbonate and increases lactic acidosis risk with metformin. Requires mor…
Dichlorphenamide + Saxagliptin And Metformin Hydrochloride— Carbonic anhydrase inhibitor causing metabolic acidosis. Concomitant use may increase risk of metformin-associated lacti…
Dichlorphenamide + Sitagliptin And Metformin Hydrochloride— Carbonic anhydrase inhibitor that decreases serum bicarbonate and induces metabolic acidosis, increasing risk for lactic…
Dichlorphenamide + Zonisamide— Concomitant carbonic anhydrase inhibitor use may increase severity of metabolic acidosis and risk of kidney stone format…

Moderate (10)

Dichlorphenamide + Andthiazide— Increased risk of hypokalemia with coadministration of dichlorphenamide and thiazide diuretics.
Dichlorphenamide + Aspirin (Low-Dose)— Low-dose aspirin with dichlorphenamide requires careful monitoring due to increased salicylate toxicity risk.
Dichlorphenamide + Azole Antifungals— Increased risk of hypokalemia with coadministration of dichlorphenamide and antifungals.
Dichlorphenamide + Canagliflozin And Metformin Hydrochloride— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis when used with I…
Dichlorphenamide + Cytochrome P450-Metabolized Drugs— Coadministration may increase severity of metabolic acidosis.
Dichlorphenamide + Glyburide-Metformin Hydrochloride— Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis with glyburide-m…
Dichlorphenamide + Laxatives— Increased risk of hypokalemia with coadministration of dichlorphenamide and laxatives.
Dichlorphenamide + Loop Diuretics— Increased risk of hypokalemia with coadministration of dichlorphenamide and loop diuretics.
Dichlorphenamide + Penicillin— Increased risk of hypokalemia with coadministration of dichlorphenamide and penicillins.
Dichlorphenamide + Theophylline— Increased risk of hypokalemia with coadministration of dichlorphenamide and theophylline.

Dichlorphenamide + Aspirin⛔Contraindicated

High-dose aspirin with dichlorphenamide is contraindicated due to risk of anorexia, tachypnea, lethargy, and coma. Low-dose aspirin requires careful monitoring.

Dichlorphenamide + Aspirin (High-Dose)⛔Contraindicated

High-dose aspirin with dichlorphenamide causes anorexia, tachypnea, lethargy, and coma. Concomitant use is contraindicated.

Dichlorphenamide + Alogliptin And Metformin Hydrochloride⚠️Major

Carbonic anhydrase inhibitor that may increase risk of lactic acidosis by decreasing serum bicarbonate and inducing metabolic acidosis.

Dichlorphenamide + Dapagliflozin And Metformin Hydrochloride⚠️Major

Carbonic anhydrase inhibitor that may increase risk for lactic acidosis when used concomitantly.

Dichlorphenamide + Empagliflozin And Metformin Hydrochloride⚠️Major

Dichlorphenamide causes decreased serum bicarbonate and metabolic acidosis; concomitant use may increase risk of lactic acidosis.

Dichlorphenamide + Empagliflozin, Linagliptin, Metformin Hydrochloride⚠️Major

Dichlorphenamide causes decreased serum bicarbonate and metabolic acidosis; concomitant use with TRIJARDY XR may increase risk of lactic acidosis.

Dichlorphenamide + Empagliflozin, Metformin Hydrochloride⚠️Major

Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk of lactic acidosis when used with SYNJARDY or SYNJARDY XR.

Dichlorphenamide + Ertugliflozin And Metformin Hydrochloride⚠️Major

Increases risk of lactic acidosis due to decreased serum bicarbonate and metabolic acidosis when used with metformin.

Dichlorphenamide + Famotidine⚠️Major

Concomitant use is not recommended as dichlorphenamide inhibits OAT1 transporters, increasing famotidine plasma exposure.

Dichlorphenamide + Glyburide And Metformin Hydrochloride⚠️Major

Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis when used with glyburide and metformin hydrochloride.

Dichlorphenamide + Linagliptin And Metformin Hydrochloride⚠️Major

Carbonic anhydrase inhibitor that decreases serum bicarbonate and induces metabolic acidosis, increasing risk of lactic acidosis with linagliptin and metformin.

Dichlorphenamide + Metformin⚠️Major

Carbonic anhydrase inhibitor that decreases serum bicarbonate and induces metabolic acidosis, increasing risk for lactic acidosis when used with metformin.

Dichlorphenamide + Metformin Er 500 Mg⚠️Major

Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk of lactic acidosis with metformin.

Dichlorphenamide + Metformin Hydrochloride⚠️Major

Carbonic anhydrase inhibitor that may increase risk of lactic acidosis by decreasing serum bicarbonate and inducing metabolic acidosis.

Dichlorphenamide + Metformin Hydrochloride Extended-Release Tablets⚠️Major

Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis when used with metformin.

Dichlorphenamide + Metformin Hydrochloride Tablet⚠️Major

Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis when used with metformin.

Dichlorphenamide + Methotrexate⚠️Major

Concomitant use is not recommended as dichlorphenamide inhibits OAT1 transporters, increasing methotrexate plasma exposure.

Dichlorphenamide + Oseltamivir⚠️Major

Concomitant use is not recommended as dichlorphenamide inhibits OAT1 transporters, increasing oseltamivir plasma exposure.

Dichlorphenamide + Pioglitazole And Metformin Hydrochloride⚠️Major

Carbonic anhydrase inhibitor decreases serum bicarbonate and increases lactic acidosis risk with metformin. Requires more frequent monitoring.

Dichlorphenamide + Saxagliptin And Metformin Hydrochloride⚠️Major

Carbonic anhydrase inhibitor causing metabolic acidosis. Concomitant use may increase risk of metformin-associated lactic acidosis.

Dichlorphenamide + Sitagliptin And Metformin Hydrochloride⚠️Major

Carbonic anhydrase inhibitor that decreases serum bicarbonate and induces metabolic acidosis, increasing risk for lactic acidosis when used with JANUMET.

Dichlorphenamide + Zonisamide⚠️Major

Concomitant carbonic anhydrase inhibitor use may increase severity of metabolic acidosis and risk of kidney stone formation or hyperammonemia. Monitor for metabolic acidosis worsening.

Dichlorphenamide + Andthiazide🟡Moderate

Increased risk of hypokalemia with coadministration of dichlorphenamide and thiazide diuretics.

Dichlorphenamide + Aspirin (Low-Dose)🟡Moderate

Low-dose aspirin with dichlorphenamide requires careful monitoring due to increased salicylate toxicity risk.

Dichlorphenamide + Azole Antifungals🟡Moderate

Increased risk of hypokalemia with coadministration of dichlorphenamide and antifungals.

Dichlorphenamide + Canagliflozin And Metformin Hydrochloride🟡Moderate

Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis when used with INVOKAMET. Consider more frequent monitoring.

Dichlorphenamide + Cytochrome P450-Metabolized Drugs🟡Moderate

Coadministration may increase severity of metabolic acidosis.

Dichlorphenamide + Glyburide-Metformin Hydrochloride🟡Moderate

Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis with glyburide-metformin.

Dichlorphenamide + Laxatives🟡Moderate

Increased risk of hypokalemia with coadministration of dichlorphenamide and laxatives.

Dichlorphenamide + Loop Diuretics🟡Moderate

Increased risk of hypokalemia with coadministration of dichlorphenamide and loop diuretics.

Dichlorphenamide + Penicillin🟡Moderate

Increased risk of hypokalemia with coadministration of dichlorphenamide and penicillins.

Dichlorphenamide + Theophylline🟡Moderate

Increased risk of hypokalemia with coadministration of dichlorphenamide and theophylline.

Dichlorphenamide + Glipizide And Metformin Hydrochlorideℹ️Unknown

Other Carbonic Anhydrase Inhibitors Topiramate or other carbonic anhydrase inhibitors (e.g., zonisamide, acetazolamide or dichlorphenamide) frequently causes a decrease in serum bicarbonate and induce non-anion gap, hyperchloremic metabolic acidosis.

Dichlorphenamide + Topiramateℹ️Unknown

7.6 Other Carbonic Anhydrase Inhibitors Concomitant use of topiramate, a carbonic anhydrase inhibitor, with any other carbonic anhydrase inhibitor (e.g., zonisamide, acetazolamide, or dichlorphenamide) may increase the severity of metabolic acidosis and may also increase the risk of kidney stone formation.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.