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Terazosin

Also known as: Tezruly

Route: Oral

31 interactions on record

Terazosin has 31 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Midodrine Hydrochloride, Vardenafil, Propranolol Hydrochloride. Patients taking Terazosin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 31
Major: 2
Moderate: 3
Minor: 23

Major (2)

Terazosin + Midodrine Hydrochloride— Alpha-adrenergic blocking agent can antagonize the effects of midodrine hydrochloride.
Terazosin + Vardenafil— Alpha-blocker interaction with additive blood pressure lowering effects. Clinical pharmacology studies conducted; cautio…

Moderate (3)

Terazosin + Propranolol Hydrochloride— Postural hypotension reported in patients taking both beta-blockers and terazosin.
Terazosin + Vardenafil Hydrochloride— Caution is advised when vardenafil is co-administered with terazosin. Both are vasodilators with blood-pressure-lowering…
Terazosin + Verapamil— Verapamil increases terazosin AUC by 11-24%, Cmax by 25%, and Cmin by 32% after 3 weeks of concomitant use, with decreas…

Minor (23)

Terazosin + Acetaminophen— Terazosin has been used concomitantly with acetaminophen in at least 50 patients with no interactions observed.
Terazosin + Allopurinol— Terazosin has been used concomitantly with allopurinol in at least 50 patients with no interactions observed.
Terazosin + Aspirin— Terazosin has been used concomitantly with aspirin in at least 50 patients with no interactions observed.
Terazosin + Atenolol— Terazosin has been added to atenolol in controlled trials with no unexpected interactions observed.
Terazosin + Captopril— Concomitant administration of captopril does not influence captopril plasma disposition; terazosin maximum plasma concen…
Terazosin + Chlorpheniramine— Terazosin has been used concomitantly with chlorpheniramine in at least 50 patients with no interactions observed.
Terazosin + Codeine— Terazosin has been used concomitantly with codeine in at least 50 patients with no interactions observed.
Terazosin + Diazepam— Terazosin has been used concomitantly with diazepam in at least 50 patients with no interactions observed.
Terazosin + Diuretics— Terazosin added to diuretics in controlled trials with no unexpected interactions observed.
Terazosin + Dutasteride— Administration of dutasteride in combination with terazosin has no effect on the steady-state pharmacokinetics of terazo…
Terazosin + Erythromycin— Terazosin has been used concomitantly with erythromycin in at least 50 patients with no interactions observed.
Terazosin + Hydrochlorothiazide— Terazosin has been added to hydrochlorothiazide in controlled trials with no unexpected interactions observed.
Terazosin + Ibuprofen— Terazosin has been used concomitantly with ibuprofen in at least 50 patients with no interactions observed.
Terazosin + Indomethacin— Terazosin has been used concomitantly with indomethacin in at least 50 patients with no interactions observed.
Terazosin + Methyclothiazide— Terazosin has been used concomitantly with methyclothiazide in at least 50 patients with no interactions observed.
Terazosin + Nonselective Beta-Adrenergic Antagonists— Terazosin has been combined with several beta-adrenergic blockers in controlled trials with no unexpected interactions o…
Terazosin + Phenylephrine Hydrochloride— Terazosin has been used concomitantly with phenylephrine hydrochloride in at least 50 patients with no interactions obse…
Terazosin + Phenylpropanolamine Hydrochloride— Terazosin has been used concomitantly with phenylpropanolamine hydrochloride in at least 50 patients with no interaction…
Terazosin + Propranolol— Terazosin has been added to propranolol in controlled trials with no unexpected interactions observed.
Terazosin + Pseudoephedrine Hydrochloride— Terazosin has been used concomitantly with pseudoephedrine hydrochloride in at least 50 patients with no interactions ob…
Terazosin + Sulfamethoxazole— Terazosin has been used concomitantly with sulfamethoxazole in at least 50 patients with no interactions observed.
Terazosin + Sulfamethoxazole And Trimethoprim— Used concomitantly in at least 50 patients with no interactions observed.
Terazosin + Trimethoprim— Terazosin has been used concomitantly with trimethoprim in at least 50 patients with no interactions observed.

Terazosin + Midodrine Hydrochloride⚠️Major

Alpha-adrenergic blocking agent can antagonize the effects of midodrine hydrochloride.

Terazosin + Vardenafil⚠️Major

Alpha-blocker interaction with additive blood pressure lowering effects. Clinical pharmacology studies conducted; caution advised when co-administered.

Terazosin + Propranolol Hydrochloride🟡Moderate

Postural hypotension reported in patients taking both beta-blockers and terazosin.

Terazosin + Vardenafil Hydrochloride🟡Moderate

Caution is advised when vardenafil is co-administered with terazosin. Both are vasodilators with blood-pressure-lowering effects; additive effect on blood pressure may be anticipated.

Terazosin + Verapamil🟡Moderate

Verapamil increases terazosin AUC by 11-24%, Cmax by 25%, and Cmin by 32% after 3 weeks of concomitant use, with decreased Tmax from 1.3 to 0.8 hours.

Terazosin + Acetaminophen🟢Minor

Terazosin has been used concomitantly with acetaminophen in at least 50 patients with no interactions observed.

Terazosin + Allopurinol🟢Minor

Terazosin has been used concomitantly with allopurinol in at least 50 patients with no interactions observed.

Terazosin + Aspirin🟢Minor

Terazosin has been used concomitantly with aspirin in at least 50 patients with no interactions observed.

Terazosin + Atenolol🟢Minor

Terazosin has been added to atenolol in controlled trials with no unexpected interactions observed.

Terazosin + Captopril🟢Minor

Concomitant administration of captopril does not influence captopril plasma disposition; terazosin maximum plasma concentrations increase linearly with dose at steady-state.

Terazosin + Chlorpheniramine🟢Minor

Terazosin has been used concomitantly with chlorpheniramine in at least 50 patients with no interactions observed.

Terazosin + Codeine🟢Minor

Terazosin has been used concomitantly with codeine in at least 50 patients with no interactions observed.

Terazosin + Diazepam🟢Minor

Terazosin has been used concomitantly with diazepam in at least 50 patients with no interactions observed.

Terazosin + Diuretics🟢Minor

Terazosin added to diuretics in controlled trials with no unexpected interactions observed.

Terazosin + Dutasteride🟢Minor

Administration of dutasteride in combination with terazosin has no effect on the steady-state pharmacokinetics of terazosin.

Terazosin + Erythromycin🟢Minor

Terazosin has been used concomitantly with erythromycin in at least 50 patients with no interactions observed.

Terazosin + Hydrochlorothiazide🟢Minor

Terazosin has been added to hydrochlorothiazide in controlled trials with no unexpected interactions observed.

Terazosin + Ibuprofen🟢Minor

Terazosin has been used concomitantly with ibuprofen in at least 50 patients with no interactions observed.

Terazosin + Indomethacin🟢Minor

Terazosin has been used concomitantly with indomethacin in at least 50 patients with no interactions observed.

Terazosin + Methyclothiazide🟢Minor

Terazosin has been used concomitantly with methyclothiazide in at least 50 patients with no interactions observed.

Terazosin + Nonselective Beta-Adrenergic Antagonists🟢Minor

Terazosin has been combined with several beta-adrenergic blockers in controlled trials with no unexpected interactions observed.

Terazosin + Phenylephrine Hydrochloride🟢Minor

Terazosin has been used concomitantly with phenylephrine hydrochloride in at least 50 patients with no interactions observed.

Terazosin + Phenylpropanolamine Hydrochloride🟢Minor

Terazosin has been used concomitantly with phenylpropanolamine hydrochloride in at least 50 patients with no interactions observed.

Terazosin + Propranolol🟢Minor

Terazosin has been added to propranolol in controlled trials with no unexpected interactions observed.

Terazosin + Pseudoephedrine Hydrochloride🟢Minor

Terazosin has been used concomitantly with pseudoephedrine hydrochloride in at least 50 patients with no interactions observed.

Terazosin + Sulfamethoxazole🟢Minor

Terazosin has been used concomitantly with sulfamethoxazole in at least 50 patients with no interactions observed.

Terazosin + Sulfamethoxazole And Trimethoprim🟢Minor

Used concomitantly in at least 50 patients with no interactions observed.

Terazosin + Trimethoprim🟢Minor

Terazosin has been used concomitantly with trimethoprim in at least 50 patients with no interactions observed.

Terazosin + Prazosinℹ️Unknown

This lesion has also been seen with prazosin hydrochloride, another (marketed) selective-alpha-1 blocking agent.

Terazosin + Terazosin Hydrochlorideℹ️Unknown

Drug Interactions In controlled trials, terazosin have been added to diuretics, and several beta-adrenergic blockers; no unexpected interactions were observed. Terazosin has also been used in patients on a variety of concomitant therapies; while these were not formal interaction studies, no interactions were observed. Terazosin has been used concomitantly in at least 50 patients on the following drugs or drug classes: analgesic/anti-inflammatory (e.g., acetaminophen, aspirin, codeine, ibuprofen, indomethacin); antibiotics (e.g., erythromycin, trimethoprim and sulfamethoxazole); anticholinergic/sympathomimetics (e.g., phenylephrine hydrochloride, phenylpropanolamine hydrochloride, pseudoephedrine hydrochloride); antigout (e.g., allopurinol); antihistamines (e.g., chlorpheniramine); cardiovascular agents (e.g., atenolol, hydrochlorothiazide, methyclothiazide, propranolol); corticosteroids; gastrointestinal agents (e.g., antacids); hypoglycemics; sedatives and tranquilizers (e.g., diazepam).

Terazosin + Trandolapril And Verapamil Hydrochlorideℹ️Unknown

There are reports that verapamil may result in higher concentrations of the alpha-agonists prazosin and terazosin.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.