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Valacyclovir

Route: Oral

Check Valacyclovir Interactions →
20 interactions on record

Valacyclovir has 20 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Alafenamide, Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate, Efavirenz, Emtricitabine And Tenofovir Disoproxil Fumarate. Patients taking Valacyclovir should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total
20
Moderate
14

Moderate (14)

Valacyclovir + Mycophenolate Mofetil🟡Moderate

Drug Interactions with Mycophenolate Mofetil that Affect Other Drugs Drugs that Undergo Renal Tubular Secretion Clinical Impact When concomitantly used with mycophenolate mofetil, its metabolite MPAG, may compete with drugs eliminated by renal tubular secretion which may increase plasma concentrations and/or adverse reactions associated with these drugs Prevention or Management Monitor for drug-related adverse reactions in patients with renal impairment Examples Acyclovir, ganciclovir, probenecid, valacyclovir, valganciclovir Combination Oral Contraceptives Clinical Impact Concomitant use with mycophenolate mofetil decreased the systemic exposure to levonorgestrel, but did not affect the systemic exposure to ethinylestradiol [see Clinical Pharmacology ( 12.3 )], which may result in reduced combination oral contraceptive effectiveness.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.