Montelukast has 18 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Warfarin Sodium, Gemfibrozil, Propranolol Hydrochloride. Patients taking Montelukast should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 18
- Major
- 1
- Moderate
- 3
- Minor
- 14
Major (1)
- Montelukast + Warfarin Sodium— CYP1A2 and CYP3A4 inducer that decreases warfarin effect and INR; requires close monitoring.
Moderate (3)
- Montelukast + Gemfibrozil— Gemfibrozil is a strong CYP2C8 inhibitor that may increase montelukast exposure; dosing reduction may be required.
- Montelukast + Propranolol Hydrochloride— CYP1A2 inducer that decreases propranolol plasma levels, resulting in loss of efficacy.
- Montelukast + Repaglinide— CYP2C8 inhibitor. Repaglinide dose reductions and increased glucose monitoring may be required.
Minor (14)
- Montelukast + Decongestants— No dose adjustment needed when co-administered with montelukast sodium.
- Montelukast + Digoxin— No dose adjustment needed when co-administered with montelukast sodium.
- Montelukast + Fexofenadine— No dose adjustment needed when co-administered with montelukast sodium.
- Montelukast + Itraconazole— No dose adjustment needed when co-administered with montelukast sodium.
- Montelukast + Nitrazepam— No dose adjustment needed when co-administered with montelukast sodium.
- Montelukast + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)— No dose adjustment needed when co-administered with montelukast sodium.
- Montelukast + Oral Contraceptives— No dose adjustment needed when co-administered with montelukast sodium.
- Montelukast + Prednisolone— No dose adjustment needed when co-administered with montelukast sodium.
- Montelukast + Prednisone— No dose adjustment needed when co-administered with montelukast sodium.
- Montelukast + Sedative-Hypnotics— No dose adjustment needed when co-administered with montelukast sodium.
- Montelukast + Terfenadine— No dose adjustment needed when co-administered with montelukast sodium.
- Montelukast + Theophylline— No dose adjustment needed when co-administered with montelukast sodium.
- Montelukast + Thyroid Hormones— No dose adjustment needed when co-administered with montelukast sodium.
- Montelukast + Warfarin— No dose adjustment needed when co-administered with montelukast sodium.