Darunavir%2C Cobicistat%2C Emtricitabine%2C And Tenofovir Alafenam + Darunavir Interaction
Unknowninteraction on record
Description
7.2 Potential for SYMTUZA to Affect Other Drugs Darunavir co-administered with cobicistat is an inhibitor of CYP3A and CYP2D6. 7.3 Potential for Other Drugs to Affect SYMTUZA Darunavir is metabolized by CYP3A. Co-administration of drugs that induce CYP3A activity are expected to increase the clearance of darunavir and cobicistat, resulting in lowered plasma concentrations which may lead to loss of therapeutic effect and development of resistance.
Source: FDA drug label - darunavir, cobicistat, emtricitabine, and tenofovir alafenamide