Drospirenone%2C Ethinyl Estradiol And Levomefolate Calcium And Levomefolate Calcium + Midazolam Interaction
Moderateinteraction on record
Description
COCs Increasing the Plasma Concentrations of CYP450 Enzymes : In clinical studies, administration of a hormonal contraceptive containing EE did not lead to any increase or only to a weak increase in plasma concentrations of CYP3A4 substrates (e.g., midazolam) while plasma concentrations of CYP2C19 substrates (e.g., omeprazole and voriconazole) and CYP1A2 substrates (e.g., theophylline and tizanidine) can have a weak or moderate increase.
Source: FDA drug label - drospirenone, ethinyl estradiol and levomefolate calcium and levomefolate calcium