Elvitegravir%2C Cobicistat%2C Emtricitabine%2C And Tenofovir Alafenamide + Midazolam Interaction
Contraindicatedinteraction on record
Description
Sedative/hypnotic: midazolam (oral) triazolam ↑ midazolam ↑ triazolam Coadministration with triazolam or orally administered midazolam is contraindicated due to potential for serious and/or life-threatening reactions such as prolonged or increased sedation or respiratory depression. Other benzodiazepines: e.g., parenterally administered midazolam clorazepate diazepam estazolam flurazepam ↑ sedatives/hypnotics Triazolam and orally administered midazolam are extensively metabolized by CYP3A. Coadministration of triazolam or orally administered midazolam with GENVOYA may cause large increases in the concentrations of these benzodiazepines.
Source: FDA drug label - elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide