Elvitegravir%2C Cobicistat%2C Emtricitabine%2C And Tenofovir Disop + Prednisolone Interaction
Unknowninteraction on record
Description
Corticosteroids: e.g., betamethasone budesonide ciclesonide dexamethasone fluticasone methylprednisolone mometasone triamcinolone ↓ elvitegravir ↓ cobicistat ↑ corticosteroids Coadministration with oral dexamethasone or other systemic corticosteroids that induce CYP3A may result in loss of therapeutic effect and development of resistance to elvitegravir. Alternative corticosteroids including beclomethasone, prednisone, and prednisolone (whose PK and/or PD are less affected by strong CYP3A inhibitors relative to other studied steroids) should be considered, particularly for long-term use.
Source: FDA drug label - elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate