Naltrexone Hydrochloride has 5 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Antidiabetic Medicines, Opioid Analgesics, Disulfiram. Patients taking Naltrexone Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 5
- Major
- 2
- Moderate
- 3
Major (2)
- Naltrexone Hydrochloride + Antidiabetic Medicines— Patients may not benefit from opioid-containing medicines. In emergency situations, greater opioid amounts may be requir…
- Naltrexone Hydrochloride + Opioid Analgesics— Patients may not benefit from opioid analgesia. Amount required may be greater than usual with deeper and more prolonged…
Moderate (3)
- Naltrexone Hydrochloride + Disulfiram— Safety and efficacy of concomitant use is unknown. Concomitant use of two potentially hepatotoxic medications is not ord…
- Naltrexone Hydrochloride + Iron-Containing Preparations— Patients taking naltrexone hydrochloride may not benefit from opioid-containing cough and cold preparations.
- Naltrexone Hydrochloride + Thioridazine— Lethargy and somnolence have been reported following doses of naltrexone hydrochloride when used concomitantly with thio…