Pentosan polysulfate sodium does not significantly alter warfarin pharmacokinetics or INR values, but use with caution in patients receiving anticoagulant therapies.
Source: NLP:pentosan polysulfate sodium
Pentosan Polysulfate Sodium Interactions
Brand names: Elmiron
Route: Oral
Contraindications
CONTRAINDICATIONS ELMIRON ® is contraindicated in patients with known hypersensitivity to the drug, structurally related compounds, or excipients.
Pregnancy & Breastfeeding
Pregnancy Reproduction studies have been performed in mice and rats with intravenous daily doses of 15 mg/kg, and in rabbits with 7.5 mg/kg. These doses are 0.42 and 0.14 times the daily oral human doses of ELMIRON ® when normalized to body surface area. These studies did not reveal evidence of impaired fertility or harm to the fetus from ELMIRON ® . Direct in vitro bathing of cultured mouse embryos with pentosan polysulfate sodium (PPS) at a concentration of 1 mg/mL may cause reversible limb bud abnormalities. Adequate and well-controlled studies have not been performed in pregnant women. Because animal studies are not always predictive of human response, this drug should be used in pregnancy only if clearly needed.
1 interaction on record