Diphenhydramine Hydrochloride has 4 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Alcohol, Mao Inhibitors, Sedatives. Patients taking Diphenhydramine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 4
- Moderate
- 4
Moderate (4)
- Diphenhydramine Hydrochloride + Alcohol— Additive CNS depressant effects with diphenhydramine hydrochloride.
- Diphenhydramine Hydrochloride + Mao Inhibitors— MAO inhibitors prolong and intensify the anticholinergic (drying) effects of diphenhydramine hydrochloride.
- Diphenhydramine Hydrochloride + Sedatives— Additive CNS depressant effects with diphenhydramine hydrochloride.
- Diphenhydramine Hydrochloride + Tranquilizers— Additive CNS depressant effects with diphenhydramine hydrochloride.