Monitor heart rate; sinus bradycardia resulting in hospitalization and pacemaker insertion has been reported with some calcium channel blockers.
Source: NLP:clonidine hydrochloride
Clonidine Hydrochloride Interactions
Brand names: Clonidine Hydrochloride
Route: Oral
FDA Black Box Warning
NOTE: Duraclon ® (epidural clonidine) is not recommended for obstetrical, post-partum, or peri-operative pain management. The risk of hemodynamic instability, especially hypotension and bradycardia, from epidural clonidine may be unacceptable in these patients. However, in a rare obstetrical, post-partum or peri-operative patient, potential benefits may outweigh the possible risks.
Contraindications
CONTRAINDICATIONS Clonidine hydrochloride tablets should not be used in patients with known hypersensitivity to clonidine (see PRECAUTIONS ).
Pregnancy & Breastfeeding
Pregnancy Teratogenic Effects : Pregnancy Category C Reproduction studies performed in rabbits at doses up to approximately 3 times the oral maximum recommended daily human dose (MRDHD) of clonidine hydrochloride tablets produced no evidence of a teratogenic or embryotoxic potential in rabbits. In rats, however, doses as low as 1/3 the oral MRDHD (1/15 the MRDHD on a mg/m 2 basis) of clonidine were associated with increased resorptions in a study in which dams were treated continuously from 2 months prior to mating. Increased resorptions were not associated with treatment at the same time or at higher dose levels (up to 3 times the oral MRDHD) when the dams were treated on gestation days 6 to 15. Increases in resorption were observed at much higher dose levels (40 times the oral MRDHD on a mg/kg basis; 4 to 8 times the MRDHD on a mg/m 2 basis) in mice and rats treated on gestation days 1 to 14 (lowest dose employed in the study was 500 µg/kg). No adequate, well-controlled studies have been conducted in pregnant women. Clonidine crosses the placental barrier (see CLINICAL PHARMACOLOGY, Pharmacokinetics ) . Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
10 interactions on record
Potentiate sedating effects of clonidine. Avoid use.
Source: NLP:clonidine hydrochloride
Potential for additive effects such as bradycardia and AV block. Caution is warranted.
Source: NLP:clonidine hydrochloride
Sinus bradycardia resulting in hospitalization and pacemaker insertion has been reported with concomitant use of clonidine and diltiazem.
Source: NLP:clonidine hydrochloride
High intravenous doses of clonidine may increase arrhythmogenic potential (QT-prolongation, ventricular fibrillation) of high intravenous doses of haloperidol, though causal relationship unclear.
Source: NLP:clonidine hydrochloride
Potentiate bradycardia and risk of AV block. Caution is warranted.
Source: NLP:clonidine hydrochloride
Sinus bradycardia resulting in hospitalization and pacemaker insertion has been reported with concomitant use of clonidine and verapamil.
Source: NLP:clonidine hydrochloride
Clonidine may potentiate the CNS-depressive effects of alcohol.
Source: NLP:clonidine hydrochloride
Amitriptyline in combination with clonidine enhances corneal lesion manifestation in animal studies; reduces hypotensive effect of clonidine.
Source: NLP:clonidine hydrochloride
Clonidine may potentiate the CNS-depressive effects of barbiturates.
Source: NLP:clonidine hydrochloride