Iobenguane I-123 has 14 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amiodarone Hydrochloride, Dronedarone, Droperidol. Patients taking Iobenguane I-123 should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 14
- Contraindicated
- 3
- Major
- 1
- Moderate
- 10
Contraindicated (3)
- Iobenguane I-123 + Amiodarone Hydrochloride— Increased risk of Torsade de Pointes. Avoid concomitant use.
- Iobenguane I-123 + Dronedarone— Contraindicated due to potential risk of torsade de pointes-type ventricular tachycardia.
- Iobenguane I-123 + Droperidol— Class I antiarrhythmics should not be used together with droperidol due to potential QT prolongation and arrhythmia risk…
Major (1)
- Iobenguane I-123 + Glycopyrrolate— Potential for additive anticholinergic interaction resulting in increased anticholinergic adverse reactions.
Moderate (10)
- Iobenguane I-123 + Amitriptyline— Antidepressant that inhibits norepinephrine transporter function, potentially decreasing iobenguane uptake and causing f…
- Iobenguane I-123 + Cocaine— Drug that may decrease norepinephrine uptake and cause false negative imaging results with iobenguane.
- Iobenguane I-123 + Ephedrine— Sympathomimetic amine that may decrease norepinephrine uptake and cause false negative imaging results with iobenguane.
- Iobenguane I-123 + Imipramine— Antidepressant that inhibits norepinephrine transporter function, potentially decreasing iobenguane uptake and causing f…
- Iobenguane I-123 + Labetalol— Antihypertensive that depletes norepinephrine stores or inhibits reuptake, potentially decreasing iobenguane uptake and …
- Iobenguane I-123 + Phenylephrine Hci— Sympathomimetic amine that may decrease norepinephrine uptake and cause false negative imaging results with iobenguane.
- Iobenguane I-123 + Phenylpropanolamine— Sympathomimetic amine that may decrease norepinephrine uptake and cause false negative imaging results with iobenguane.
- Iobenguane I-123 + Pseudoephedrine— Sympathomimetic amine that may decrease norepinephrine uptake and cause false negative imaging results with iobenguane.
- Iobenguane I-123 + Reserpine— Antihypertensive that depletes norepinephrine stores or inhibits reuptake, potentially decreasing iobenguane uptake and …
- Iobenguane I-123 + Selective Serotonin Reuptake Inhibitors (Ssri)— Antidepressants that inhibit norepinephrine transporter function, causing potential false negative imaging results. Disc…