Apraclonidine has 9 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Mao Inhibitors, Alcohol, Barbiturates. Patients taking Apraclonidine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 9
- Contraindicated
- 1
- Moderate
- 8
Contraindicated (1)
- Apraclonidine + Mao Inhibitors— Apraclonidine should not be used in patients receiving MAO inhibitors.
Moderate (8)
- Apraclonidine + Alcohol— Possibility of additive or potentiating effect with CNS depressants.
- Apraclonidine + Barbiturates— Possibility of additive or potentiating effect with CNS depressants.
- Apraclonidine + Cardiac Glycosides— Caution advised as apraclonidine may reduce pulse and blood pressure.
- Apraclonidine + Clonidine— Caution advised with simultaneous use of clonidine and other similar pharmacologic agents.
- Apraclonidine + Insulin Human— Apraclonidine may inhibit catecholamine production in response to insulin-induced hypoglycemia and mask hypoglycemia sig…
- Apraclonidine + Nonselective Beta-Adrenergic Antagonists— Caution advised due to potential additive hypotensive and pulse-reducing effects.
- Apraclonidine + Sedatives— Possibility of additive or potentiating effect with CNS depressants.
- Apraclonidine + Topical Local Anesthetics— Possibility of additive or potentiating effect with CNS depressants.