Lidocaine Patch 5% has 32 known drug interactions based on U.S. FDA drug labeling data. 30 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetaminophen, Acetazolamide, Articaine. Patients taking Lidocaine Patch 5% should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 32
- Major
- 30
- Moderate
- 2
Major (30)
- Lidocaine Patch 5% + Acetaminophen— Increased risk of methemoglobinemia; drugs associated with methemoglobinemia when used with local anesthetics.
- Lidocaine Patch 5% + Acetazolamide— Increased risk of methemoglobinemia; antibiotics associated with methemoglobinemia when used with local anesthetics.
- Lidocaine Patch 5% + Articaine— Increased risk of methemoglobinemia when concurrently exposed; local anesthetics have additive risk when used concomitan…
- Lidocaine Patch 5% + Benzocaine— Increased risk of methemoglobinemia when concurrently exposed; local anesthetics have additive risk when used concomitan…
- Lidocaine Patch 5% + Bupivacaine— Increased risk of methemoglobinemia when concurrently exposed; local anesthetics have additive risk when used concomitan…
- Lidocaine Patch 5% + Chloroquine— Increased risk of methemoglobinemia; antimalarials associated with methemoglobinemia when used with local anesthetics.
- Lidocaine Patch 5% + Cyclophosphamide— Increased risk of methemoglobinemia; antineoplastic agents associated with methemoglobinemia when used with local anesth…
- Lidocaine Patch 5% + Dapsone— Increased risk of methemoglobinemia; antibiotics associated with methemoglobinemia when used with local anesthetics.
- Lidocaine Patch 5% + Flutamide— Increased risk of methemoglobinemia; antineoplastic agents associated with methemoglobinemia when used with local anesth…
- Lidocaine Patch 5% + Hydroxyurea— Increased risk of methemoglobinemia; antineoplastic agents associated with methemoglobinemia when used with local anesth…
- Lidocaine Patch 5% + Ifosfamide— Increased risk of methemoglobinemia; antineoplastic agents associated with methemoglobinemia when used with local anesth…
- Lidocaine Patch 5% + Mepivacaine— Increased risk of methemoglobinemia when concurrently exposed; local anesthetics have additive risk when used concomitan…
- Lidocaine Patch 5% + Metoclopramide— Increased risk of methemoglobinemia; drugs associated with methemoglobinemia when used with local anesthetics.
- Lidocaine Patch 5% + Nitric Oxide— Increased risk of methemoglobinemia when concurrently exposed; nitrates/nitrites may cause methemoglobinemia when used w…
- Lidocaine Patch 5% + Nitrofurantoin— Increased risk of methemoglobinemia; antibiotics associated with methemoglobinemia when used with local anesthetics.
- Lidocaine Patch 5% + Nitroglycerin— Increased risk of methemoglobinemia when concurrently exposed; nitrates/nitrites may cause methemoglobinemia when used w…
- Lidocaine Patch 5% + Nitroprusside— Increased risk of methemoglobinemia when concurrently exposed; nitrates/nitrites may cause methemoglobinemia when used w…
- Lidocaine Patch 5% + Nitrous Oxide— Increased risk of methemoglobinemia when concurrently exposed; nitrates/nitrites may cause methemoglobinemia when used w…
- Lidocaine Patch 5% + Para-Aminosalicylic Acid— Increased risk of methemoglobinemia; antibiotics associated with methemoglobinemia when used with local anesthetics.
- Lidocaine Patch 5% + Phenobarbital— Increased risk of methemoglobinemia; anticonvulsants associated with methemoglobinemia when used with local anesthetics.
- Lidocaine Patch 5% + Phenytoin— Increased risk of methemoglobinemia; anticonvulsants associated with methemoglobinemia when used with local anesthetics.
- Lidocaine Patch 5% + Prilocaine— Increased risk of methemoglobinemia when concurrently exposed; local anesthetics have additive risk when used concomitan…
- Lidocaine Patch 5% + Primaquine— Increased risk of methemoglobinemia; antimalarials associated with methemoglobinemia when used with local anesthetics.
- Lidocaine Patch 5% + Procaine— Increased risk of methemoglobinemia when concurrently exposed; local anesthetics have additive risk when used concomitan…
- Lidocaine Patch 5% + Quinine— Increased risk of methemoglobinemia; drugs associated with methemoglobinemia when used with local anesthetics.
- Lidocaine Patch 5% + Rasburicase— Increased risk of methemoglobinemia; antineoplastic agents associated with methemoglobinemia when used with local anesth…
- Lidocaine Patch 5% + Ropivacaine— Increased risk of methemoglobinemia when concurrently exposed; local anesthetics have additive risk when used concomitan…
- Lidocaine Patch 5% + Sulfasalazine— Increased risk of methemoglobinemia; drugs associated with methemoglobinemia when used with local anesthetics.
- Lidocaine Patch 5% + Tetracaine— Increased risk of methemoglobinemia when concurrently exposed; local anesthetics have additive risk when used concomitan…
- Lidocaine Patch 5% + Valproate Sodium— Increased risk of methemoglobinemia; anticonvulsants associated with methemoglobinemia when used with local anesthetics.
Moderate (2)
- Lidocaine Patch 5% + Mexiletine— Toxic effects are additive and potentially synergistic; use with caution in patients receiving Class I antiarrhythmic dr…
- Lidocaine Patch 5% + Tocainide— Toxic effects are additive and potentially synergistic; use with caution in patients receiving Class I antiarrhythmic dr…