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Deutetrabenazine

Also known as: Austedo, Austedo, Austedo Xr

Route: Oral

Check Deutetrabenazine Interactions →
10 interactions on record⛔ Black Box Warning

Deutetrabenazine has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Monoamine Oxidase Inhibitors (Maois), Reserpine, Tetrabenazine. Patients taking Deutetrabenazine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total
10
Contraindicated
4
Major
5
Moderate
1

Contraindicated (4)

Major (5)

  • Deutetrabenazine + Bupropion— Strong CYP2D6 inhibitor that increases systemic exposure to active dihydro-metabolites of deutetrabenazine by approximat…
  • Deutetrabenazine + Dopamine Agonists— Concomitant use may increase risk of parkinsonism, neuroleptic malignant syndrome, and akathisia.
  • Deutetrabenazine + Fluoxetine— Strong CYP2D6 inhibitor that increases systemic exposure to active dihydro-metabolites of deutetrabenazine by approximat…
  • Deutetrabenazine + Paroxetine— Strong CYP2D6 inhibitor that increases systemic exposure to active dihydro-metabolites of deutetrabenazine by approximat…
  • Deutetrabenazine + Quinidine— Strong CYP2D6 inhibitor that increases systemic exposure to active dihydro-metabolites of deutetrabenazine by approximat…

Moderate (1)

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.