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Guanfacine Hydrochloride

Also known as: Guanfacine Hydrochloride

Central alpha-2 Adrenergic AgonistAdrenergic alpha2-Agonists

Route: Oral

Check Guanfacine Hydrochloride Interactions →

4 interactions on record

Guanfacine Hydrochloride has 4 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Cns-Depressant Drugs, Phenobarbital, Phenytoin. Patients taking Guanfacine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 4
Moderate: 3
Minor: 1

Moderate (3)

Guanfacine Hydrochloride + Cns-Depressant Drugs— Potential for increased sedation when guanfacine is given with other CNS-depressant drugs.
Guanfacine Hydrochloride + Phenobarbital— Microsomal enzyme inducer that significantly reduces guanfacine elimination half-life and plasma concentration, particul…
Guanfacine Hydrochloride + Phenytoin— Microsomal enzyme inducer that significantly reduces guanfacine elimination half-life and plasma concentration, particul…

Minor (1)

Guanfacine Hydrochloride + Oral Anticoagulants— No changes in anticoagulation observed when guanfacine 1-2 mg/day was given to patients stabilized on oral anticoagulant…

Guanfacine Hydrochloride + Cns-Depressant Drugs🟡Moderate

Potential for increased sedation when guanfacine is given with other CNS-depressant drugs.

Guanfacine Hydrochloride + Phenobarbital🟡Moderate

Microsomal enzyme inducer that significantly reduces guanfacine elimination half-life and plasma concentration, particularly in renal impairment patients, requiring more frequent dosing.

Guanfacine Hydrochloride + Phenytoin🟡Moderate

Microsomal enzyme inducer that significantly reduces guanfacine elimination half-life and plasma concentration, particularly in renal impairment patients, requiring more frequent dosing.

Guanfacine Hydrochloride + Oral Anticoagulants🟢Minor

No changes in anticoagulation observed when guanfacine 1-2 mg/day was given to patients stabilized on oral anticoagulants for 4 weeks.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.