Difenoxin And Atropine Sulfate has 4 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Monoamine Oxidase Inhibitors (Maois), Alcohol, Barbiturates. Patients taking Difenoxin And Atropine Sulfate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 4
- Major
- 1
- Moderate
- 3
Major (1)
- Difenoxin And Atropine Sulfate + Monoamine Oxidase Inhibitors (Maois)— Concurrent use may precipitate a hypertensive crisis due to structural similarity to meperidine.
Moderate (3)
- Difenoxin And Atropine Sulfate + Alcohol— MOTOFEN may potentiate the action of alcohol; patient should be closely monitored.
- Difenoxin And Atropine Sulfate + Barbiturates— MOTOFEN may potentiate the action of barbiturates; patient should be closely monitored.
- Difenoxin And Atropine Sulfate + Tranquilizers— MOTOFEN may potentiate the action of tranquilizers; patient should be closely monitored.