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Avapritinib

Also known as: Ayvakit

Kinase InhibitorTyrosine Kinase InhibitorsCytochrome P450 2C9 Inhibitors

Route: Oral

Check Avapritinib Interactions →
3 interactions on record

Avapritinib has 3 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cyp3a Inducers, Mao Inhibitors, Ethinyl Estradiol. Patients taking Avapritinib should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total
3
Major
2
Moderate
1

Major (2)

  • Avapritinib + Cyp3a InducersCoadministration decreases avapritinib plasma concentrations, which may decrease efficacy of AYVAKIT. Avoid coadministra
  • Avapritinib + Mao InhibitorsCoadministration increases avapritinib plasma concentrations, which may increase incidence and severity of adverse react

Moderate (1)

  • Avapritinib + Ethinyl EstradiolAvapritinib may increase ethinyl estradiol exposure, leading to increased risk of ethinyl estradiol-associated adverse r

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.