Phentolamine mesylate administration did not affect the pharmacokinetics of epinephrine.
Source: NLP:phentolamine mesylate
Phentolamine Mesylate Interactions
Brand names: Oraverse
Route: Submucosal
Contraindications
4. CONTRAINDICATIONS OraVerse is contraindicated in patients with: Hypersensitivity to the active substance or to any ingredients in the formulation OraVerse is contraindicated in patients with: Hypersensitivity to the active substance or to any ingredients in the formulation. ( 4 )
Pregnancy & Breastfeeding
8.1 Pregnancy Pregnancy Category C Risk summary There are no available data with OraVerse in pregnant women to inform a drug-associated risk for major birth defects and miscarriage. In animal toxicology studies, phentolamine administered orally to pregnant mice and rats during the period of organogenesis resulted in skeletal immaturity and decreased growth in the offspring at doses at least 24-times the recommended dose. Additionally, a lower rate of implantation was seen in pregnant rats treated with phentolamine at least 60-times the recommended dose. No malformations or embryofetal deaths were observed in the offspring of pregnant mice, rats, and rabbits administered phentolamine during the period of organogenesis at doses 24-, 60-, and 20-times, respectively, the recommended dose [see Data]. The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2-4% and 15-20%, respectively. Data Animal Data Oral administration of phentolamine to pregnant rats and mice at doses at least 24-times the recommended dose (based on a mg/m2 comparison with a 60 kg human) resulted in slightly decreased growth and slight skeletal immaturity of the fetuses. Immaturity was manifested by increased incidence of incomplete or unossified calcanei and phalangeal nuclei of the hind limb and of incompletely ossified sternebrae. At oral phentolamine doses at least 60-times the recommended dose (based on a mg/m2 comparison with a 60 kg human),a slightly lower rate of implantation was found in the rat. Phentolamine did not affect embryonic or fetal development in the rabbit at oral doses at least 20-times the recommended dose (based on a mg/m2 comparison with a 60 kg human). No malformations or embryofetal deaths were observed in the rat, mouse or rabbit studies. Pregnancy Category C Risk summary There are
2 interactions on record
Lidocaine concentration increased immediately after phentolamine mesylate intraoral injection, but AUC and Cmax values were not affected.
Source: NLP:phentolamine mesylate