Lofexidine Hydrochloride has 6 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Methadone, Alcohol, Barbiturates. Patients taking Lofexidine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Major
- 1
- Moderate
- 5
Major (1)
- Lofexidine Hydrochloride + Methadone— Both methadone and lofexidine prolong the QT interval. ECG monitoring is recommended when used concomitantly.
Moderate (5)
- Lofexidine Hydrochloride + Alcohol— Lofexidine may potentiate CNS depressant effects of alcohol.
- Lofexidine Hydrochloride + Barbiturates— Lofexidine may potentiate CNS depressant effects of barbiturates.
- Lofexidine Hydrochloride + Naltrexone— Concomitant use may reduce efficacy of oral naltrexone, particularly if administered within 2 hours of lofexidine. Non-o…
- Lofexidine Hydrochloride + Nitrazepam— Lofexidine potentiates CNS depressant effects of benzodiazepines.
- Lofexidine Hydrochloride + Paroxetine— CYP2D6 inhibitor paroxetine increases lofexidine plasma levels by 28%. Monitor for orthostatic hypotension and bradycard…