Melphalan Hydrochloride has 4 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carmustine, Cisplatin, Cyclosporine. Patients taking Melphalan Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 4
- Major
- 4
Major (4)
- Melphalan Hydrochloride + Carmustine— IV melphalan may reduce the threshold for BCNU lung toxicity.
- Melphalan Hydrochloride + Cisplatin— Cisplatin may affect melphalan kinetics by inducing renal dysfunction and altering melphalan clearance.
- Melphalan Hydrochloride + Cyclosporine— Severe renal failure has been reported when IV melphalan is followed by standard oral doses of cyclosporine.
- Melphalan Hydrochloride + Nalidixic Acid— Simultaneous administration of nalidixic acid and IV melphalan increases the incidence of severe hemorrhagic necrotic en…