Preclinical studies show both drugs can induce seizures in animals. Coadministration produced fewer seizures than expected, suggesting no adverse interaction likely, but seizure risk remains a potential concern.
Source: NLP:nalmefene hydrochloride
Nalmefene Hydrochloride Interactions
Brand names: Nalmefene Hydrochloride
Route: Intramuscular, Intravenous, Subcutaneous
Contraindications
CONTRAINDICATIONS Nalmefene hydrochloride injection is contraindicated in patients with a known hypersensitivity to the product.
Pregnancy & Breastfeeding
Use in Pregnancy Reproduction studies have been performed in rats (up to 1200 mg/m 2 /day) and rabbits (up to 2400 mg/m 2 /day) by oral administration of nalmefene and in rabbits by intravenous administration up to 96 mg/m 2 /day (114 times the human dose). There was no evidence of impaired fertility or harm to the fetus. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
1 interaction on record