Salicylic Acid 10% has 10 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Heparin, Methotrexate, Oral Anticoagulants. Patients taking Salicylic Acid 10% should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 10
- Major
- 3
- Moderate
- 7
Major (3)
- Salicylic Acid 10% + Heparin— Salicylate decreases platelet adhesiveness and interferes with hemostasis in heparin-treated patients.
- Salicylic Acid 10% + Methotrexate— Salicylate decreases tubular reabsorption of methotrexate, resulting in clinical toxicity.
- Salicylic Acid 10% + Oral Anticoagulants— Salicylate competition for serum albumin binding increases bleeding risk.
Moderate (7)
- Salicylic Acid 10% + Ammonium Sulfate— Increases plasma salicylate levels by altering renal tubular reabsorption.
- Salicylic Acid 10% + Corticosteroids— Corticosteroids decrease plasma salicylate levels; tapering doses may promote salicylism.
- Salicylic Acid 10% + Phenylbutazone— Salicylate inhibits the uricosuric effect of phenylbutazone.
- Salicylic Acid 10% + Probenecid— Salicylate inhibits the uricosuric effect of probenecid.
- Salicylic Acid 10% + Pyrazinamide— Salicylate inhibits pyrazinamide-induced hyperuricemia.
- Salicylic Acid 10% + Sulfinpyrazone— Salicylate inhibits the uricosuric effect of sulfinpyrazone.
- Salicylic Acid 10% + Tolbutamide— Salicylate competition for serum albumin binding potentiates hypoglycemia.