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Trilaciclib

Also known as: Cosela

Route: Intravenous

Check Trilaciclib Interactions →
3 interactions on record

Trilaciclib has 3 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cisplatin, Dalfampridine, Dofetilide. Patients taking Trilaciclib should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total
3
Major
3

Major (3)

  • Trilaciclib + Cisplatin— COSELA may increase cisplatin exposure and kidney accumulation, causing dose-related nephrotoxicity. Close monitoring re…
  • Trilaciclib + Dalfampridine— COSELA inhibits OCT2 and may increase dalfampridine blood levels, elevating risk of seizures.
  • Trilaciclib + Dofetilide— COSELA inhibits OCT2 and may increase dofetilide concentration, causing serious ventricular arrhythmias and QT interval …

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.