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Cefdinir

Also known as: Cefdinir

Cephalosporin Antibacterial

Route: Oral

11 interactions on record

Cefdinir has 11 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Iron Supplements, Probenecid, Androgen-Deprivation Therapeutic Drugs. Patients taking Cefdinir should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 11
Major: 2
Moderate: 9

Major (2)

Cefdinir + Iron Supplements— Reduces cefdinir absorption by 80% when given with 60 mg elemental iron supplement. Take cefdinir at least 2 hours befor…
Cefdinir + Probenecid— Probenecid inhibits renal excretion of cefdinir, resulting in approximately doubled AUC, 54% increase in peak plasma lev…

Moderate (9)

Cefdinir + Androgen-Deprivation Therapeutic Drugs— Concomitant administration reduces extent of cefdinir absorption by approximately 80%. Should be taken at least 2 hours …
Cefdinir + Antacids (Aluminum- Or Magnesium-Containing)— Concomitant administration reduces cefdinir absorption rate and extent by approximately 40% and prolongs time to peak by…
Cefdinir + Antacids Containing Aluminum— Reduces rate and extent of cefdinir absorption by approximately 40% and prolongs time to peak concentration by 1 hour. N…
Cefdinir + Antacids Containing Magnesium— Reduces rate and extent of cefdinir absorption by approximately 40% and prolongs time to peak concentration by 1 hour. N…
Cefdinir + Ferrous Sulfate— Therapeutic iron supplements containing 60 mg elemental iron reduce cefdinir absorption by 80%. Take cefdinir at least 2…
Cefdinir + Iron Supplements (60 Mg Elemental Iron As Feso4)— Concomitant administration reduces cefdinir absorption extent by 80%. Cefdinir should be taken at least 2 hours before o…
Cefdinir + Iron-Fortified Vitamins— Vitamins fortified with 10 mg elemental iron reduce cefdinir absorption extent by 31%. If required, cefdinir should be t…
Cefdinir + Maalox Tc (Aluminum- Or Magnesium-Containing Antacids)— Concomitant administration reduces cefdinir absorption rate and extent by approximately 40%, with delayed time to peak c…
Cefdinir + Vitamins Supplemented With Iron— Vitamins with 10 mg elemental iron reduce cefdinir absorption extent by 31%. Separate dosing by at least 2 hours.

Cefdinir + Iron Supplements⚠️Major

Reduces cefdinir absorption by 80% when given with 60 mg elemental iron supplement. Take cefdinir at least 2 hours before or after iron supplement.

Cefdinir + Probenecid⚠️Major

Probenecid inhibits renal excretion of cefdinir, resulting in approximately doubled AUC, 54% increase in peak plasma levels, and 50% prolongation in elimination half-life.

Cefdinir + Androgen-Deprivation Therapeutic Drugs🟡Moderate

Concomitant administration reduces extent of cefdinir absorption by approximately 80%. Should be taken at least 2 hours before or after iron supplement. Forms nonabsorbable complex in GI tract.

Cefdinir + Antacids (Aluminum- Or Magnesium-Containing)🟡Moderate

Concomitant administration reduces cefdinir absorption rate and extent by approximately 40% and prolongs time to peak by 1 hour. No significant effects if antacid is given 2+ hours before or after cefdinir.

Cefdinir + Antacids Containing Aluminum🟡Moderate

Reduces rate and extent of cefdinir absorption by approximately 40% and prolongs time to peak concentration by 1 hour. No significant effect if administered 2 hours before or after cefdinir.

Cefdinir + Antacids Containing Magnesium🟡Moderate

Reduces rate and extent of cefdinir absorption by approximately 40% and prolongs time to peak concentration by 1 hour. No significant effect if administered 2 hours before or after cefdinir.

Cefdinir + Ferrous Sulfate🟡Moderate

Therapeutic iron supplements containing 60 mg elemental iron reduce cefdinir absorption by 80%. Take cefdinir at least 2 hours before or after iron supplement.

Cefdinir + Iron Supplements (60 Mg Elemental Iron As Feso4)🟡Moderate

Concomitant administration reduces cefdinir absorption extent by 80%. Cefdinir should be taken at least 2 hours before or after iron supplements.

Cefdinir + Iron-Fortified Vitamins🟡Moderate

Vitamins fortified with 10 mg elemental iron reduce cefdinir absorption extent by 31%. If required, cefdinir should be taken at least 2 hours before or after the supplement.

Cefdinir + Maalox Tc (Aluminum- Or Magnesium-Containing Antacids)🟡Moderate

Concomitant administration reduces cefdinir absorption rate and extent by approximately 40%, with delayed time to peak concentration. Take cefdinir at least 2 hours before or after antacid.

Cefdinir + Vitamins Supplemented With Iron🟡Moderate

Vitamins with 10 mg elemental iron reduce cefdinir absorption extent by 31%. Separate dosing by at least 2 hours.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.