Probenecid inhibits renal excretion of cefdinir, resulting in approximately doubled AUC, 54% increase in peak plasma levels, and 50% prolongation in elimination half-life.
Source: NLP:cefdinir
Cefdinir Interactions
Brand names: Cefdinir
Cephalosporin Antibacterial
Route: Oral
Contraindications
CONTRAINDICATIONS Cefdinir is contraindicated in patients with known allergy to the cephalosporin class of antibiotics.
Pregnancy & Breastfeeding
Pregnancy: Teratogenic Effects: Pregnancy Category B. Cefdinir was not teratogenic in rats at oral doses up to 1000 mg/kg/day (70 times the human dose based on mg/kg/day, 11 times based on mg/m 2 /day) or in rabbits at oral doses up to 10 mg/kg/day (0.7 times the human dose based on mg/kg/day, 0.23 times based on mg/m 2 /day). Maternal toxicity (decreased body weight gain) was observed in rabbits at the maximum tolerated dose of 10 mg/kg/day without adverse effects on offspring. Decreased body weight occurred in rat fetuses at ≥100 mg/kg/day, and in rat offspring at ≥32 mg/kg/day. No effects were observed on maternal reproductive parameters or offspring survival, development, behavior, or reproductive function. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
8 interactions on record
Concomitant administration reduces cefdinir absorption rate and extent by approximately 40% and prolongs time to peak by 1 hour. No significant effects if antacid is given 2+ hours before or after cefdinir.
Source: NLP:cefdinir
Reduces rate and extent of cefdinir absorption by approximately 40% and prolongs time to peak concentration by 1 hour. No significant effect if administered 2 hours before or after cefdinir.
Source: NLP:cefdinir
Reduces rate and extent of cefdinir absorption by approximately 40% and prolongs time to peak concentration by 1 hour. No significant effect if administered 2 hours before or after cefdinir.
Source: NLP:cefdinir
Cefdinir + Iron SupplementsModerate
Therapeutic iron supplements (60 mg elemental iron) reduce cefdinir absorption extent by 80%. Cefdinir should be taken at least 2 hours before or after iron supplements.
Source: NLP:cefdinir
Concomitant administration reduces cefdinir absorption extent by 80%. Cefdinir should be taken at least 2 hours before or after iron supplements.
Source: NLP:cefdinir
Vitamins fortified with 10 mg elemental iron reduce cefdinir absorption extent by 31%. If required, cefdinir should be taken at least 2 hours before or after the supplement.
Source: NLP:cefdinir
Vitamins with 10 mg elemental iron reduce cefdinir absorption extent by 31%. Separate dosing by at least 2 hours.
Source: NLP:cefdinir