Cefdinir has 11 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Iron Supplements, Probenecid, Androgen-Deprivation Therapeutic Drugs. Patients taking Cefdinir should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Major
- 2
- Moderate
- 9
Major (2)
- Cefdinir + Iron Supplements— Reduces cefdinir absorption by 80% when given with 60 mg elemental iron supplement. Take cefdinir at least 2 hours befor…
- Cefdinir + Probenecid— Probenecid inhibits renal excretion of cefdinir, resulting in approximately doubled AUC, 54% increase in peak plasma lev…
Moderate (9)
- Cefdinir + Androgen-Deprivation Therapeutic Drugs— Concomitant administration reduces extent of cefdinir absorption by approximately 80%. Should be taken at least 2 hours …
- Cefdinir + Antacids (Aluminum- Or Magnesium-Containing)— Concomitant administration reduces cefdinir absorption rate and extent by approximately 40% and prolongs time to peak by…
- Cefdinir + Antacids Containing Aluminum— Reduces rate and extent of cefdinir absorption by approximately 40% and prolongs time to peak concentration by 1 hour. N…
- Cefdinir + Antacids Containing Magnesium— Reduces rate and extent of cefdinir absorption by approximately 40% and prolongs time to peak concentration by 1 hour. N…
- Cefdinir + Ferrous Sulfate— Therapeutic iron supplements containing 60 mg elemental iron reduce cefdinir absorption by 80%. Take cefdinir at least 2…
- Cefdinir + Iron Supplements (60 Mg Elemental Iron As Feso4)— Concomitant administration reduces cefdinir absorption extent by 80%. Cefdinir should be taken at least 2 hours before o…
- Cefdinir + Iron-Fortified Vitamins— Vitamins fortified with 10 mg elemental iron reduce cefdinir absorption extent by 31%. If required, cefdinir should be t…
- Cefdinir + Maalox Tc (Aluminum- Or Magnesium-Containing Antacids)— Concomitant administration reduces cefdinir absorption rate and extent by approximately 40%, with delayed time to peak c…
- Cefdinir + Vitamins Supplemented With Iron— Vitamins with 10 mg elemental iron reduce cefdinir absorption extent by 31%. Separate dosing by at least 2 hours.