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Drospirenone And Estetrol

Also known as: Nextstellis

Check Drospirenone And Estetrol Interactions →

5 interactions on record⛔ Black Box Warning

Drospirenone And Estetrol has 5 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cyp3a Inducers, Bile Acid Binding Resins, Cyp3a Inducers (Moderate And Weak). Patients taking Drospirenone And Estetrol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 5
Contraindicated: 1
Major: 3
Moderate: 1

Contraindicated (1)

Drospirenone And Estetrol + Cyp3a Inducers— Strong CYP3A inducers decrease DRSP exposure, leading to contraceptive failure and breakthrough bleeding. Avoid concomit…

Major (3)

Drospirenone And Estetrol + Bile Acid Binding Resins— Bile acid sequestrants decrease E4 and DRSP exposure, potentially leading to contraceptive failure and breakthrough blee…
Drospirenone And Estetrol + Cyp3a Inducers (Moderate And Weak)— Moderate and weak CYP3A inducers may decrease DRSP exposure, potentially leading to contraceptive failure and breakthrou…
Drospirenone And Estetrol + Mao Inhibitors— Strong CYP3A inhibitors increase DRSP exposure, increasing risk of adverse reactions including hyperkalemia.

Moderate (1)

Drospirenone And Estetrol + Diuretics— NEXTSTELLIS may reduce the blood glucose lowering effect of anti-diabetic drugs, requiring increased glucose monitoring …

Drospirenone And Estetrol + Cyp3a Inducers⛔Contraindicated

Strong CYP3A inducers decrease DRSP exposure, leading to contraceptive failure and breakthrough bleeding. Avoid concomitant use.

Drospirenone And Estetrol + Bile Acid Binding Resins⚠️Major

Bile acid sequestrants decrease E4 and DRSP exposure, potentially leading to contraceptive failure and breakthrough bleeding.

Drospirenone And Estetrol + Cyp3a Inducers (Moderate And Weak)⚠️Major

Moderate and weak CYP3A inducers may decrease DRSP exposure, potentially leading to contraceptive failure and breakthrough bleeding.

Drospirenone And Estetrol + Mao Inhibitors⚠️Major

Strong CYP3A inhibitors increase DRSP exposure, increasing risk of adverse reactions including hyperkalemia.

Drospirenone And Estetrol + Diuretics🟡Moderate

NEXTSTELLIS may reduce the blood glucose lowering effect of anti-diabetic drugs, requiring increased glucose monitoring and dosage adjustment.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.