Midazolam In 0.8% Sodium Chloride has 16 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Fentanyl, Meperidine, Morphine. Patients taking Midazolam In 0.8% Sodium Chloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 16
- Major
- 3
- Moderate
- 10
Major (3)
- Midazolam In 0.8% Sodium Chloride + Fentanyl— Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites. Sedative effect…
- Midazolam In 0.8% Sodium Chloride + Meperidine— Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites. Sedative effect…
- Midazolam In 0.8% Sodium Chloride + Morphine— Concomitant use increases risk of respiratory depression due to actions at different CNS receptor sites. Sedative effect…
Moderate (10)
- Midazolam In 0.8% Sodium Chloride + Cimetidine— P450-3A4 inhibitor may result in prolonged sedation due to decreased plasma clearance of midazolam.
- Midazolam In 0.8% Sodium Chloride + Diltiazem— P450-3A4 inhibitor may result in prolonged sedation. Increases midazolam half-life from 5 to 7 hours.
- Midazolam In 0.8% Sodium Chloride + Droperidol— CNS depressant that accentuates the sedative effect of intravenous midazolam. Dosage adjustment recommended.
- Midazolam In 0.8% Sodium Chloride + Erythromycin— P450-3A4 inhibitor may result in prolonged sedation. Reduces clearance of midazolam and approximately doubles half-life.
- Midazolam In 0.8% Sodium Chloride + Itraconazole— P450-3A4 inhibitor may result in prolonged sedation due to decreased plasma clearance of midazolam.
- Midazolam In 0.8% Sodium Chloride + Ketoconazole— P450-3A4 inhibitor may result in prolonged sedation due to decreased plasma clearance of midazolam.
- Midazolam In 0.8% Sodium Chloride + Saquinavir— Reduces clearance of midazolam by 56% and approximately doubles half-life, resulting in prolonged sedation.
- Midazolam In 0.8% Sodium Chloride + Secobarbital— CNS depressant that accentuates the sedative effect of intravenous midazolam. Dosage adjustment recommended.
- Midazolam In 0.8% Sodium Chloride + Thiopental— Moderate reduction in induction dosage requirements of thiopental (about 15%) when used concomitantly with midazolam.
- Midazolam In 0.8% Sodium Chloride + Verapamil— P450-3A4 inhibitor may result in prolonged sedation. Increases midazolam half-life from 5 to 7 hours.