Daridorexant has 4 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Cyp3a Inducers, Mao Inhibitors, Alcohol. Patients taking Daridorexant should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 4
- Contraindicated
- 2
- Major
- 2
Contraindicated (2)
- Daridorexant + Cyp3a Inducers— Concomitant use with strong CYP3A4 inducers decreases daridorexant exposure and may reduce efficacy. Concomitant use is …
- Daridorexant + Mao Inhibitors— Concomitant use with strong CYP3A4 inhibitors increases daridorexant exposure and risk of adverse reactions. Concomitant…
Major (2)
- Daridorexant + Alcohol— Concomitant use of alcohol with daridorexant may lead to additive impairment of psychomotor performance and CNS depressi…
- Daridorexant + Cns Depressants— Concomitant use of CNS depressants with daridorexant may lead to additive impairment of psychomotor performance and CNS …