Cevimeline might interfere with desirable antimuscarinic effects of drugs used concomitantly.
Source: NLP:cevimeline hydrochloride
Cevimeline Hydrochloride Interactions
Brand names: Cevimeline Hydrochloride
Route: Oral
Contraindications
CONTRAINDICATIONS Cevimeline is contraindicated in patients with uncontrolled asthma, known hypersensitivity to cevimeline, and when miosis is undesirable, e.g., in acute iritis and in narrow-angle (angle-closure) glaucoma.
Pregnancy & Breastfeeding
Pregnancy: Pregnancy Category C. Cevimeline was associated with a reduction in the mean number of implantations when given to pregnant Sprague-Dawley rats from 14 days prior to mating through day seven of gestation at a dosage of 45 mg/kg/day (approximately 5 times the maximum recommended dose for a 60 kg human when compared on the basis of body surface area estimates). This effect may have been secondary to maternal toxicity. There are no adequate and well-controlled studies in pregnant women. Cevimeline should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
4 interactions on record
Drugs which inhibit CYP2D6 also inhibit the metabolism of cevimeline, requiring caution in use.
Source: NLP:cevimeline hydrochloride
Cevimeline should be administered with caution due to the possibility of conduction disturbances when used concurrently with beta adrenergic antagonists.
Source: NLP:cevimeline hydrochloride
Drugs with parasympathomimetic effects administered concurrently with cevimeline can be expected to have additive effects.
Source: NLP:cevimeline hydrochloride