Ganaxolone has 6 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Alcohol, Carbamazepine, Phenobarbital. Patients taking Ganaxolone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Moderate
- 6
Moderate (6)
- Ganaxolone + Alcohol— CNS depressant that may increase risk of somnolence and sedation when used concomitantly with ganaxolone.
- Ganaxolone + Carbamazepine— CYP3A4 inducer that decreases ganaxolone exposure and efficacy; ZTALMY dosage may need to be increased but should not ex…
- Ganaxolone + Phenobarbital— CYP3A4 inducer that decreases ganaxolone exposure and efficacy; ZTALMY dosage may need to be increased but should not ex…
- Ganaxolone + Phenytoin— CYP3A4 inducer that decreases ganaxolone exposure and efficacy; ZTALMY dosage may need to be increased but should not ex…
- Ganaxolone + Primidone— CYP3A4 inducer that decreases ganaxolone exposure and efficacy; ZTALMY dosage may need to be increased but should not ex…
- Ganaxolone + Valproic Acid— UGT inhibitor that may increase ganaxolone exposure and risk of adverse reactions; consider reduction of ZTALMY dosage w…