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Omaveloxolone

Also known as: Skyclarys

Cytochrome P450 3A4 InducersCytochrome P450 2C8 Inducers

Route: Oral

3 interactions on record

Omaveloxolone has 3 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Mao Inhibitors, Oral Contraceptives, Strong Or Moderate Cyp3a Inducers. Patients taking Omaveloxolone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 3
Major: 3

Major (3)

Omaveloxolone + Mao Inhibitors— Concomitant use results in clinically significant increased exposure of omaveloxolone, which may increase the risk of ad…
Omaveloxolone + Oral Contraceptives— Omaveloxolone weakly induces CYP3A4, which may reduce the efficacy of hormonal contraceptives. Avoid concomitant use wit…
Omaveloxolone + Strong Or Moderate Cyp3a Inducers— Concomitant use results in clinically significant decreased exposure of omaveloxolone, which may reduce the effectivenes…

Omaveloxolone + Mao Inhibitors⚠️Major

Concomitant use results in clinically significant increased exposure of omaveloxolone, which may increase the risk of adverse reactions. Avoid concomitant use; if unavoidable, dosage reduction with monitoring is recommended.

Omaveloxolone + Oral Contraceptives⚠️Major

Omaveloxolone weakly induces CYP3A4, which may reduce the efficacy of hormonal contraceptives. Avoid concomitant use with combined hormonal contraceptives, implants, and progestin-only pills.

Omaveloxolone + Strong Or Moderate Cyp3a Inducers⚠️Major

Concomitant use results in clinically significant decreased exposure of omaveloxolone, which may reduce the effectiveness of SKYCLARYS. Avoid concomitant use.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.