Cyclobenzaprine Hcl Er + Mao InhibitorsContraindicated
Life-threatening interaction with MAO inhibitors; serotonin syndrome reported during combined use.
Source: NLP:cyclobenzaprine hcl er
Cyclobenzaprine Hcl Er Interactions
Brand names: Cyclobenzaprine Hcl Er
Route: Oral
Contraindications
Hypersensitivity to any component of this product. These adverse reactions may manifest as an anaphylactic reaction, urticaria, facial and/or tongue swelling, or pruritus. Discontinue cyclobenzaprine hydrochloride extended-release capsules if a hypersensitivity reaction is suspected. Concomitant use of monoamine oxidase (MAO) inhibitors or within 14 days after their discontinuation. Hyperpyretic crisis seizures and deaths have occurred in patients receiving cyclobenzaprine (or structurally similar tricyclic antidepressants) concomitantly with MAO inhibitor drugs. During the acute recovery phase of myocardial infarction, and in patients with arrhythmias, heart block or conduction disturbances, or congestive heart failure. Hyperthyroidism.
9 interactions on record
Postmarketing cases of serotonin syndrome reported during combined use with bupropion.
Source: NLP:cyclobenzaprine hcl er
Postmarketing cases of serotonin syndrome reported during combined use with meperidine.
Source: NLP:cyclobenzaprine hcl er
Postmarketing cases of serotonin syndrome reported during combined use with tricyclic antidepressants.
Source: NLP:cyclobenzaprine hcl er
May enhance seizure risk and serotonin syndrome has been reported during combined use.
Source: NLP:cyclobenzaprine hcl er
Postmarketing cases of serotonin syndrome reported during combined use with verapamil.
Source: NLP:cyclobenzaprine hcl er
Cyclobenzaprine Hcl Er + AlcoholModerate
Cyclobenzaprine may enhance the effects of alcohol.
Source: NLP:cyclobenzaprine hcl er
Cyclobenzaprine may enhance the effects of barbiturates.
Source: NLP:cyclobenzaprine hcl er
Cyclobenzaprine may block the antihypertensive action of guanethidine.
Source: NLP:cyclobenzaprine hcl er