Methylphenidate Hydrochloride Extended Release has 12 known drug interactions based on U.S. FDA drug labeling data. Of these, 6 are contraindicated combinations that should be avoided entirely. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Isocarboxazid, Linezolid, Methylene Blue. Patients taking Methylphenidate Hydrochloride Extended Release should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 12
- Contraindicated
- 6
- Major
- 5
- Moderate
- 1
Contraindicated (6)
- Methylphenidate Hydrochloride Extended Release + Isocarboxazid— Concomitant use can cause hypertensive crisis with potential outcomes including death, stroke, myocardial infarction, ao…
- Methylphenidate Hydrochloride Extended Release + Linezolid— Concomitant use can cause hypertensive crisis with potential outcomes including death, stroke, myocardial infarction, ao…
- Methylphenidate Hydrochloride Extended Release + Methylene Blue— Concomitant use can cause hypertensive crisis with potential outcomes including death, stroke, myocardial infarction, ao…
- Methylphenidate Hydrochloride Extended Release + Phenelzine— Concomitant use can cause hypertensive crisis with potential outcomes including death, stroke, myocardial infarction, ao…
- Methylphenidate Hydrochloride Extended Release + Selegiline— Concomitant use can cause hypertensive crisis with potential outcomes including death, stroke, myocardial infarction, ao…
- Methylphenidate Hydrochloride Extended Release + Tranylcypromine— Concomitant use can cause hypertensive crisis with potential outcomes including death, stroke, myocardial infarction, ao…
Major (5)
- Methylphenidate Hydrochloride Extended Release + Desflurane— Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid on day of surge…
- Methylphenidate Hydrochloride Extended Release + Enflurane— Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid on day of surge…
- Methylphenidate Hydrochloride Extended Release + Halothane— Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid on day of surge…
- Methylphenidate Hydrochloride Extended Release + Isoflurane— Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid on day of surge…
- Methylphenidate Hydrochloride Extended Release + Sevoflurane— Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid on day of surge…
Moderate (1)
- Methylphenidate Hydrochloride Extended Release + Risperidone— Combined use with dosage changes may increase risk of extrapyramidal symptoms. Monitor for signs of EPS.