Diphenoxylate Hydrochloride And Atropine Sulfate has 9 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Mao Inhibitors, Monoamine Oxidase Inhibitors (Maois), Alcohol. Patients taking Diphenoxylate Hydrochloride And Atropine Sulfate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 9
- Contraindicated
- 2
- Moderate
- 6
Contraindicated (2)
- Diphenoxylate Hydrochloride And Atropine Sulfate + Mao Inhibitors— Diphenoxylate may interact with MAOIs and precipitate hypertensive crisis. Avoid use and monitor for hypertensive crisis…
- Diphenoxylate Hydrochloride And Atropine Sulfate + Monoamine Oxidase Inhibitors (Maois)— MAOIs may interact with diphenoxylate and precipitate hypertensive crisis. Avoid use and monitor for signs including hea…
Moderate (6)
- Diphenoxylate Hydrochloride And Atropine Sulfate + Alcohol— Alcohol may increase CNS depressant effects and cause drowsiness. Concomitant use should be avoided.
- Diphenoxylate Hydrochloride And Atropine Sulfate + Antihistamines— May potentiate CNS depressant effects of diphenoxylate hydrochloride and atropine sulfate. Monitor for CNS adverse react…
- Diphenoxylate Hydrochloride And Atropine Sulfate + Barbiturates— May potentiate CNS depressant effects of diphenoxylate hydrochloride and atropine sulfate. Monitor for CNS adverse react…
- Diphenoxylate Hydrochloride And Atropine Sulfate + Buspirone— May potentiate CNS depressant effects of diphenoxylate hydrochloride and atropine sulfate. Monitor for CNS adverse react…
- Diphenoxylate Hydrochloride And Atropine Sulfate + Muscle Relaxants— May potentiate CNS depressant effects of diphenoxylate hydrochloride and atropine sulfate. Monitor for CNS adverse react…
- Diphenoxylate Hydrochloride And Atropine Sulfate + Nitrazepam— May potentiate CNS depressant effects of diphenoxylate hydrochloride and atropine sulfate. Monitor for CNS adverse react…